{"id":"W4417520740","doi":"10.1177/13524585251398682","title":"Managing reactivation of multiple sclerosis during treatment with natalizumab","year":2025,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Université de Montréal","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Trish Multiple Sclerosis Research Foundation; EMD Serono; Sanofi; Multiple Sclerosis International Federation; Eisai; National Research Foundation; Multiple Sclerosis Australia; Università di Catania; Biogen; Celgene; Alnylam Pharmaceuticals; International Progressive MS Alliance; Universität Basel; Sanofi Genzyme; F. Hoffmann-La Roche; Monash University; Alexion Pharmaceuticals; Medical Research Council; Teva Pharmaceutical Industries; Bayer HealthCare; European Commission; Atara Biotherapeutics; Bristol-Myers Squibb","keywords":"Natalizumab; Multiple sclerosis; Dimethyl fumarate; Progressive multifocal leukoencephalopathy; Fingolimod; Clinical trial; Central nervous system disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004859048,0.0004981807,0.0009527516,0.000978752,0.0007898888,0.0001329898,0.0002872309,0.000150005,0.00009487317],"category_scores_gemma":[0.0007394318,0.0003715153,0.0003785926,0.0009983599,0.000312765,0.0004530425,0.0001810823,0.0005632972,0.00001340442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001169596,"about_ca_system_score_gemma":0.0002886762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004529596,"about_ca_topic_score_gemma":0.0001953202,"domain_scores_codex":[0.9964355,0.0001674923,0.0009421533,0.0006012251,0.001028402,0.0008252105],"domain_scores_gemma":[0.9973245,0.0004587375,0.0004649044,0.0006800432,0.0007352388,0.0003365237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003299981,0.0009096306,0.3231441,0.0003128021,0.001266905,0.00003186945,0.0007882063,0.0003362644,0.5822554,0.00001333048,0.0002844187,0.08735702],"study_design_scores_gemma":[0.0169807,0.0007732115,0.7489776,0.003022393,0.0002364823,0.00006826598,0.0009857061,0.002290895,0.2255323,0.00001708619,0.0008304043,0.0002849085],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930061,0.0009741862,0.001471959,0.001687547,0.0002260471,0.001045951,0.00004279377,0.0001200117,0.001425389],"genre_scores_gemma":[0.9876437,0.005731715,0.005501537,0.0000784797,0.0002072175,0.0001292165,0.00002373123,0.00006589317,0.0006185712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4258335,"threshold_uncertainty_score":0.9998737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08393791848612009,"score_gpt":0.2950229528524949,"score_spread":0.2110850343663748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}