{"id":"W4417520740","doi":"10.1177/13524585251398682","title":"Managing reactivation of multiple sclerosis during treatment with natalizumab","year":2025,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de Chaudière-Appalaches; Université de Montréal","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Trish Multiple Sclerosis Research Foundation; EMD Serono; Sanofi; Multiple Sclerosis International Federation; Eisai; National Research Foundation; Multiple Sclerosis Australia; Università di Catania; Biogen; Celgene; Alnylam Pharmaceuticals; International Progressive MS Alliance; Universität Basel; Sanofi Genzyme; F. Hoffmann-La Roche; Monash University; Alexion Pharmaceuticals; Medical Research Council; Teva Pharmaceutical Industries; Bayer HealthCare; European Commission; Atara Biotherapeutics; Bristol-Myers Squibb","keywords":"Natalizumab; Multiple sclerosis; Dimethyl fumarate; Progressive multifocal leukoencephalopathy; Fingolimod; Clinical trial; Central nervous system disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008759093,0.0003380908,0.0009777229,0.0006513377,0.0002741539,0.0009635781,0.0004875551,0.0003902563,0.0006299066],"category_scores_gemma":[0.02052044,0.0001579272,0.00136942,0.0005625,0.0002878936,0.0005596184,0.000540645,0.0006333424,0.00009595544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007285717,"about_ca_system_score_gemma":0.0008351018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001616822,"about_ca_topic_score_gemma":0.001825093,"domain_scores_codex":[0.9956418,0.002882234,0.0003790507,0.0002609824,0.0005397628,0.000296047],"domain_scores_gemma":[0.9864602,0.00664147,0.005599936,0.0006721427,0.0003157021,0.0003105561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004482163,0.0003220931,0.8752298,0.0007395763,0.003209226,0.0004054774,0.0003411147,0.00441,0.001288318,0.0002646761,0.0005604301,0.1087471],"study_design_scores_gemma":[0.0006613616,0.005169576,0.9704728,0.0006508561,0.003145282,0.002671634,0.0003817875,0.01062553,0.002609119,0.001214017,0.002352115,0.00004586291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883371,0.009182662,0.0009711146,0.0003528592,0.0000195455,0.00008070333,0.0001635901,0.00002321688,0.0008691665],"genre_scores_gemma":[0.9981206,0.001274986,0.0003500359,0.00007150299,0.00002457747,0.00002376688,0.00009240282,0.00000350224,0.00003860145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008759093,"threshold_uncertainty_score":0.04632306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08393791848612009,"score_gpt":0.2950229528524949,"score_spread":0.2110850343663748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}