{"id":"W4417521185","doi":"10.1038/s41598-025-33151-y","title":"Altered PTPN13–β-catenin interaction by pathogenic mutations and involvement of this axis in B-cell receptor signalling","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Agencia Estatal de Investigación; Banco Santander","keywords":"Protein tyrosine phosphatase; Gene silencing; Regulator; Haematopoiesis; Receptor tyrosine kinase; Tyrosine kinase; Signalling; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183812,0.0002865477,0.0001434102,0.0002910213,0.0001144099,0.0002676262,0.0001500354,0.0003647681,0.001358693],"category_scores_gemma":[0.0002174534,0.00009593294,0.0001542139,0.0002117957,0.0002720514,0.0001504997,0.0001846479,0.0002997355,0.0001823257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677719,"about_ca_system_score_gemma":0.0001546114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005659269,"about_ca_topic_score_gemma":0.0004705745,"domain_scores_codex":[0.9998688,0.00002352397,0.00001463463,0.00003289939,0.00003942414,0.00002065046],"domain_scores_gemma":[0.9998995,0.00001685317,0.00004335288,0.000007714691,0.00000955578,0.00002302452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152366,0.00001341659,0.003273682,0.00002419202,0.00001214829,0.001203954,0.00002221764,0.00007221508,0.9932863,0.0001912397,0.00002289992,0.001762428],"study_design_scores_gemma":[0.00003286903,0.0002480445,0.1401835,0.00001660058,0.00007709067,0.02328203,0.00009717184,0.002554115,0.829239,0.0004875415,0.003770484,0.00001138476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967269,0.001035104,0.001494651,0.00003543467,0.000006996157,0.000005703892,0.00009663167,0.00002837692,0.0005702049],"genre_scores_gemma":[0.9991203,0.0002598187,0.000347393,0.000007378408,0.000001690181,0.000002999151,0.00005462377,0.000003754324,0.0002021495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358693,"threshold_uncertainty_score":0.004545271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00928010678336834,"score_gpt":0.2498272153396933,"score_spread":0.240547108556325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}