{"id":"W4417525267","doi":"10.1007/s13555-025-01620-x","title":"Short-Term Efficacy of Lebrikizumab Versus Dupilumab in Combination with Topical Corticosteroids in Adults with Moderate-to-Severe Atopic Dermatitis: Matching-Adjusted Indirect Comparison","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"LEO Pharma; Sun Pharma; Castle Biosciences; Biogen; Celgene; Celldex Therapeutics; Mylan; Canadian Dermatology Foundation; Samsung; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer; Galderma; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Dupilumab; Atopic dermatitis; Monoclonal antibody; Clinical efficacy; Monoclonal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004133918,0.0001974644,0.0007000304,0.00033287,0.00005775832,0.00001140229,0.00008969748,0.0001946545,0.00001425164],"category_scores_gemma":[0.00001800415,0.0001579067,0.00003051025,0.0002896813,0.0001711331,0.00009085771,0.00002581485,0.0002679977,0.000002198868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003264842,"about_ca_system_score_gemma":0.00009977392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003763813,"about_ca_topic_score_gemma":0.0004183515,"domain_scores_codex":[0.9987637,0.0001557642,0.00042103,0.0002885417,0.0001205623,0.0002504413],"domain_scores_gemma":[0.9993725,0.0002153346,0.00006904732,0.0002143853,0.00005329526,0.00007547883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01636319,0.0008192504,0.9698896,0.0002394478,0.0001496984,0.0004267221,0.001662934,0.00004090042,0.00001570209,0.0007670234,0.00007663281,0.009548908],"study_design_scores_gemma":[0.02786056,0.0003575366,0.9683379,0.0006529444,0.00004611399,0.0004243771,0.0003108678,0.0005065695,0.001144827,0.000169099,0.00003919186,0.0001500307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958079,0.001348814,0.000206656,0.001240106,0.00008057663,0.0007036572,0.000003186012,0.00003855439,0.0005705539],"genre_scores_gemma":[0.9990187,0.0001683562,0.0001198741,0.000545275,0.000004307412,0.00006528502,0.00004982308,0.00001140996,0.00001700989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01149737,"threshold_uncertainty_score":0.6439247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594574462967781,"score_gpt":0.283062033313055,"score_spread":0.2671162886833772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}