{"id":"W4417525267","doi":"10.1007/s13555-025-01620-x","title":"Short-Term Efficacy of Lebrikizumab Versus Dupilumab in Combination with Topical Corticosteroids in Adults with Moderate-to-Severe Atopic Dermatitis: Matching-Adjusted Indirect Comparison","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"LEO Pharma; Sun Pharma; Castle Biosciences; Biogen; Celgene; Celldex Therapeutics; Mylan; Canadian Dermatology Foundation; Samsung; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer; Galderma; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Dupilumab; Atopic dermatitis; Monoclonal antibody; Clinical efficacy; Monoclonal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008620257,0.001758664,0.004943959,0.000898164,0.0002713325,0.001240083,0.00118593,0.001751328,0.005491673],"category_scores_gemma":[0.01190573,0.0007300614,0.009804561,0.0007385848,0.0005793527,0.0009913401,0.0009995627,0.001926772,0.0003443346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008300794,"about_ca_system_score_gemma":0.0007383708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198324,"about_ca_topic_score_gemma":0.0009782284,"domain_scores_codex":[0.9904203,0.006580761,0.0009827369,0.000953066,0.0007478768,0.0003152586],"domain_scores_gemma":[0.9935139,0.00419904,0.001451066,0.0003806842,0.0002264376,0.0002288173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8734714,0.0009315694,0.009080433,0.006556347,0.08195311,0.0000764745,0.0001030741,0.002785261,0.0008835466,0.000386271,0.0004267942,0.02334577],"study_design_scores_gemma":[0.5386497,0.1739946,0.05081521,0.001326175,0.2096077,0.0004323153,0.0002032342,0.01505622,0.002945314,0.003069039,0.003727902,0.0001724397],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441686,0.03787106,0.005463032,0.0004581402,0.0009453258,0.003476809,0.003533026,0.0001289689,0.003954913],"genre_scores_gemma":[0.9912037,0.002791749,0.002205402,0.0002674887,0.0001704861,0.001715074,0.0008511684,0.00001048814,0.0007845018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008620257,"threshold_uncertainty_score":0.04558885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594574462967781,"score_gpt":0.283062033313055,"score_spread":0.2671162886833772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}