{"id":"W4417526138","doi":"10.1186/s12951-025-03916-8","title":"Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy","year":2025,"lang":"en","type":"article","venue":"Journal of Nanobiotechnology","topic":"Boron Compounds in Chemistry","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Particle Physics","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Immune system; Immunosuppression; Sting; Cell; Pyroptosis; Immunogenic cell death; Drug delivery; Immunoadjuvant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004055512,0.0002470395,0.0006617391,0.0005041754,0.0001254307,0.00002606032,0.0002607364,0.0006728579,0.0000268434],"category_scores_gemma":[0.00116173,0.0002104079,0.0001384083,0.0005216235,0.0002545785,0.0001074743,0.000170455,0.000958571,0.00000396872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952295,"about_ca_system_score_gemma":0.0002140257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001649918,"about_ca_topic_score_gemma":0.000001340377,"domain_scores_codex":[0.9982882,0.00005323769,0.0008162669,0.0002664359,0.000253623,0.0003222345],"domain_scores_gemma":[0.9982087,0.0003906589,0.0006438331,0.0003911729,0.0002799672,0.00008566812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002988163,0.0002305148,0.0008335444,0.0001511076,0.0002578505,0.00009306771,0.00005852254,0.00000730385,0.9690854,0.0002611029,0.0002560112,0.02846679],"study_design_scores_gemma":[0.003120221,0.0004350743,0.007290567,0.0005762008,0.000144111,0.0007464259,0.0003336096,0.000134448,0.9783351,0.0004811218,0.008217725,0.0001853393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822846,0.00200671,0.005493914,0.009177757,0.0004262159,0.0001884836,0.000001909585,0.0001298377,0.0002905525],"genre_scores_gemma":[0.9969627,0.0004267207,0.001918029,0.0002464216,0.0001056427,0.000005362761,0.000009786743,0.00002655816,0.0002988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02828145,"threshold_uncertainty_score":0.8580185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009743527079163795,"score_gpt":0.2622227673136803,"score_spread":0.2524792402345165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}