{"id":"W4417530841","doi":"10.1016/j.esmorc.2025.100102","title":"NRG-DT001 PHASE IB TRIAL OF NEOADJUVANT NAVTEMADLIN AND RADIOTHERAPY IN TP53 WILD-TYPE SOFT TISSUE SARCOMA: PRELIMINARY EFFICACY ANALYSIS","year":2025,"lang":"en","type":"article","venue":"ESMO rare cancers.","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Soft tissue sarcoma; Radiation therapy; Tolerability; Soft tissue; Sarcoma; Clinical trial; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002098338,0.0002600464,0.001006491,0.0005351044,0.00005535974,0.00001601596,0.0001139147,0.0001468573,0.0002141031],"category_scores_gemma":[0.00009982463,0.0002211032,0.0001997099,0.001271308,0.0001201225,0.00007463141,0.00003883564,0.0001800461,0.000002379352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004042135,"about_ca_system_score_gemma":0.0003566481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001334139,"about_ca_topic_score_gemma":0.0002008284,"domain_scores_codex":[0.9983391,0.0001016221,0.0005389358,0.0004807198,0.0002505421,0.0002890602],"domain_scores_gemma":[0.9988047,0.0003357834,0.0001526467,0.0004945326,0.00008693003,0.0001253693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1240937,0.007851469,0.1545779,0.0004058016,0.006368833,0.001420904,0.002249327,0.0008797604,0.00106506,0.0002829843,0.008774274,0.6920299],"study_design_scores_gemma":[0.5569036,0.01190938,0.3617879,0.001677466,0.008183632,0.00005245706,0.0006726491,0.004397047,0.01438113,0.0002962632,0.03890818,0.0008302332],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956458,0.03947091,0.0001257168,0.001909669,0.0003278638,0.001227903,0.00002936712,0.00004077969,0.0004097882],"genre_scores_gemma":[0.9950492,0.003170456,0.0006113251,0.0004543223,0.0001400716,0.0001116971,0.0000893758,0.00002299433,0.0003505726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6911997,"threshold_uncertainty_score":0.9016325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758124853013332,"score_gpt":0.3460718606338129,"score_spread":0.3284906121036796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}