{"id":"W4417530898","doi":"10.1016/j.esmorc.2025.100059","title":"DISSECTING TUMOR HETEROGENEITY AND CELL STATE-SPECIFIC THERAPEUTIC TARGETS FROM SINGLE-NUCLEI RNA-SEQ OF CIC::DUX4 ROUND CELL SARCOMA","year":2025,"lang":"en","type":"article","venue":"ESMO rare cancers.","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Sarcoma; Cell; Tumor cells; Clear-cell sarcoma; Chemotherapy; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150861,0.0001754516,0.0002833574,0.0002642487,0.0003587578,0.0006142058,0.0001808573,0.0003475508,0.001842359],"category_scores_gemma":[0.0003442918,0.0002189158,0.0001880503,0.0001941469,0.0002556464,0.0002765565,0.0002413529,0.0005433402,0.000568272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003674906,"about_ca_system_score_gemma":0.000316833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002148634,"about_ca_topic_score_gemma":0.006838044,"domain_scores_codex":[0.9998376,0.000009770716,0.000006779392,0.00006588976,0.00005402058,0.00002592218],"domain_scores_gemma":[0.999878,0.00004326398,0.00001596197,0.00001096836,0.00003467359,0.00001703431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000705592,0.000009570274,0.00175554,0.0000892871,0.00001402158,0.00003632059,0.00009112588,0.0007939531,0.9901571,0.0004588893,0.0005040675,0.006019602],"study_design_scores_gemma":[0.00002487695,0.0001128401,0.04054774,0.00003493732,0.00007595834,0.0002882802,0.0003868487,0.02751055,0.9093071,0.0008224447,0.02085552,0.00003295155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9183935,0.002413138,0.06279561,0.0003675511,0.0001709936,0.0001064646,0.006901611,0.0007246538,0.008126475],"genre_scores_gemma":[0.9620584,0.00106236,0.02567286,0.0004242259,0.00002815753,0.0001746617,0.004438208,0.0004212823,0.00571976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002148634,"threshold_uncertainty_score":0.006163299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383050455828387,"score_gpt":0.2642154732002451,"score_spread":0.2403849686419612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}