{"id":"W4417530898","doi":"10.1016/j.esmorc.2025.100059","title":"DISSECTING TUMOR HETEROGENEITY AND CELL STATE-SPECIFIC THERAPEUTIC TARGETS FROM SINGLE-NUCLEI RNA-SEQ OF CIC::DUX4 ROUND CELL SARCOMA","year":2025,"lang":"en","type":"article","venue":"ESMO rare cancers.","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Sarcoma; Cell; Tumor cells; Clear-cell sarcoma; Chemotherapy; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008601198,0.0002983768,0.0005488538,0.0001138387,0.000133467,0.00004690768,0.0001201339,0.00007656359,0.0001732021],"category_scores_gemma":[0.00001533394,0.0002584842,0.0001523806,0.0002245083,0.0001012161,0.00008352457,0.00007586076,0.0001913061,0.000008739443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005928317,"about_ca_system_score_gemma":0.0001344117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217053,"about_ca_topic_score_gemma":0.0003730125,"domain_scores_codex":[0.9984276,0.00005623236,0.0003926921,0.0005306572,0.0002356366,0.0003571416],"domain_scores_gemma":[0.9988515,0.0002516735,0.0001827593,0.0004461592,0.0001215646,0.0001462877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001093804,0.002218672,0.8167098,0.00061881,0.0008295589,0.0006600385,0.002244484,0.0000749152,0.09460497,0.00007086426,0.003046274,0.07782784],"study_design_scores_gemma":[0.004510332,0.0003937372,0.2541945,0.0003465163,0.0003085562,0.000008300271,0.001074997,0.000133375,0.7270891,0.0004966314,0.01111904,0.0003249253],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511927,0.04479362,0.00008365804,0.0003575046,0.0004638331,0.0004451719,0.0001249182,0.00005782735,0.002480734],"genre_scores_gemma":[0.9974234,0.0008402677,0.0005703853,0.0005997478,0.0001002226,0.00004852853,0.00005705158,0.0000416977,0.0003187321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6324841,"threshold_uncertainty_score":0.9999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383050455828387,"score_gpt":0.2642154732002451,"score_spread":0.2403849686419612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}