{"id":"W4417534740","doi":"10.1080/14728222.2025.2608031","title":"Harnessing mismatch repair deficiency for therapeutic targeting in cancers","year":2025,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Rally Foundation; U.S. Department of Defense","keywords":"DNA mismatch repair; Immune system; Biomarker; Cancer; Tumor microenvironment; Genome instability; Cancer treatment; Microsatellite instability","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006565534,0.0004119845,0.0006959341,0.0005098403,0.0002081514,0.001092156,0.0005686553,0.001194548,0.005308843],"category_scores_gemma":[0.0008028391,0.0001447566,0.0004809794,0.0002690656,0.0005556046,0.0008990446,0.0006409911,0.002099817,0.002227261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007536357,"about_ca_system_score_gemma":0.0005434989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003985697,"about_ca_topic_score_gemma":0.001235018,"domain_scores_codex":[0.9996557,0.00008536843,0.00002027637,0.00005394964,0.0001325637,0.0000521587],"domain_scores_gemma":[0.9996973,0.0001088969,0.0000591751,0.00001372109,0.00007862135,0.00004216336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003650276,0.0001399909,0.0009481786,0.008373746,0.0001986055,0.0009353378,0.0001583765,0.001394392,0.0840213,0.02283891,0.1281469,0.7524792],"study_design_scores_gemma":[0.00009083485,0.0003767604,0.0009131086,0.001264612,0.0001111193,0.002140938,0.0000998232,0.0008697593,0.01929843,0.008702157,0.9660999,0.00003254412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006344324,0.9452174,0.00886243,0.0217584,0.003785345,0.00009378964,0.0003246417,0.000276247,0.01333749],"genre_scores_gemma":[0.06632731,0.901379,0.005545949,0.01193614,0.003150018,0.0001257977,0.0005874875,0.00005943557,0.01088877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005308843,"threshold_uncertainty_score":0.0177598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03535287086509377,"score_gpt":0.3513386484449475,"score_spread":0.3159857775798537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}