{"id":"W4417535731","doi":"10.14814/phy2.70686","title":"The role of aging on endothelial cell–cell junctions and pulmonary microvascular permeability in male mice","year":2025,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; London Health Sciences Centre; Western University","funders":"Western University; Government of Canada; Canadian Institutes of Health Research; Government of Ontario; London Health Sciences Centre","keywords":"Adherens junction; Actin cytoskeleton; Cell junction; Cytoskeleton; VE-cadherin; Vascular permeability; Barrier function; Tight junction; Actin; Endothelial stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173369,0.0001039859,0.0001741186,0.00003242652,0.000230238,0.00001355647,0.00007200825,0.0000463464,0.00001637859],"category_scores_gemma":[0.0002899396,0.0000617894,0.00008090209,0.0001767126,0.0002571122,0.00003206957,0.00009483721,0.0001760119,0.000001919025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001406703,"about_ca_system_score_gemma":0.00001886993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004236818,"about_ca_topic_score_gemma":0.000004559714,"domain_scores_codex":[0.998949,0.0001153891,0.0002611913,0.0003990977,0.0001109474,0.0001644122],"domain_scores_gemma":[0.9993168,0.0002789833,0.00009444365,0.0002594627,0.0000248578,0.0000254561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003242014,0.00008631717,0.01034657,0.00001496146,0.000002838857,0.00002538224,0.00004242512,0.00002290197,0.9871957,0.0002812971,0.00009213963,0.00185701],"study_design_scores_gemma":[0.0001240057,0.00007032805,0.1732947,0.00001398094,0.00001449588,0.00003716314,0.0002458873,0.0000612343,0.785718,0.02406206,0.01625312,0.0001050256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830747,0.0006718092,0.00001042806,0.0001120507,0.000349177,0.0001560611,0.000002795694,0.0000187253,0.0156043],"genre_scores_gemma":[0.9986913,0.0002529237,0.00001334377,0.0002246336,0.00002826511,0.00001899153,5.593241e-7,0.000002931942,0.0007670661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2014777,"threshold_uncertainty_score":0.2519699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251685085704544,"score_gpt":0.2372711656994794,"score_spread":0.224754314842434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}