{"id":"W45844253","doi":"10.1023/a:1020625423524","title":"Phase II Study of Marimastat (BB-2516) in Malignant Melanoma – A Clinical and Tumor Biopsy Study of the National Cancer Institute of Canada Clinical Trials Group","year":2002,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Hôpital Notre-Dame; Hamilton Regional Laboratory Medicine Program; Princess Margaret Cancer Centre; Nova Scotia Cancer Centre; Ottawa Regional Cancer Foundation; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Medicine; Melanoma; Cancer; Biopsy; Internal medicine; Gastroenterology; Fibrosis; Clinical trial; Necrosis; Matrix metalloproteinase; Pathology; Oncology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002181147,0.0020869,0.002507743,0.0005508105,0.0006314402,0.0009251297,0.001136564,0.001500567,0.002829272],"category_scores_gemma":[0.0009665926,0.0008678814,0.001412167,0.0004704493,0.001053587,0.0006806513,0.0003195544,0.003383717,0.001019884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001392196,"about_ca_system_score_gemma":0.002084511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005365044,"about_ca_topic_score_gemma":0.01293539,"domain_scores_codex":[0.9993027,0.0003964841,0.00002021853,0.00007465782,0.00006714075,0.0001386811],"domain_scores_gemma":[0.9990422,0.000136892,0.0001496277,0.00007353236,0.00007273295,0.0005249829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7301524,0.05827617,0.007629356,0.0006089975,0.001657734,0.0004942435,0.0002727377,0.003339445,0.09939926,0.0004268052,0.007365368,0.09037753],"study_design_scores_gemma":[0.5344824,0.424226,0.02595367,0.00003665726,0.0006856729,0.0004704981,0.00008916762,0.001737585,0.008356847,0.0002544184,0.003654133,0.00005298093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892399,0.003387017,0.0005939495,0.0008243523,0.0002070788,0.002108051,0.001440755,0.00007986742,0.002118985],"genre_scores_gemma":[0.9804002,0.004271044,0.00210436,0.001172419,0.0003632201,0.002071235,0.003819415,0.00005519233,0.005742891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005365044,"threshold_uncertainty_score":0.01153511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1056938063737493,"score_gpt":0.3762751140693367,"score_spread":0.2705813076955874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}