{"id":"W47301690","doi":"10.1161/circ.118.suppl_18.s_361-b","title":"Abstract 1632: Tie2-Deficient Mice Exhibit Increased Susceptibility to Endothelial Apoptosis, Arteriolar Muscularization, and Pulmonary Arterial Hypertension in Response to Interleukin-6","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; St. Michael's Hospital","funders":"","keywords":"Angiopoietin receptor; Medicine; Apoptosis; Lung; Pulmonary hypertension; Internal medicine; Endocrinology; Downregulation and upregulation; Angiopoietin; Pulmonary artery; TUNEL assay; Vascular remodelling in the embryo; Receptor; Immunology; Biology; Vascular endothelial growth factor; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003131142,0.001353076,0.0006800587,0.0008947222,0.0003435267,0.0005988046,0.0003700584,0.001075478,0.01001258],"category_scores_gemma":[0.0001505799,0.0005374764,0.0004340525,0.00030175,0.0006278798,0.0004918051,0.0003433787,0.002275336,0.00209494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560477,"about_ca_system_score_gemma":0.0001616524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002476242,"about_ca_topic_score_gemma":0.0003632827,"domain_scores_codex":[0.9995878,0.00005107259,0.00005228005,0.0001080474,0.0001203665,0.00008043947],"domain_scores_gemma":[0.9993861,0.00003970092,0.0002522679,0.00003170711,0.00002111659,0.0002692293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007514597,0.0001567011,0.0003964146,0.00006275799,0.00001299709,0.0002487005,0.0000232708,0.00003499293,0.9974084,0.00006936455,0.0001150105,0.0007199672],"study_design_scores_gemma":[0.0004974917,0.003774085,0.04102401,0.00008345363,0.000107244,0.006864698,0.0002319903,0.001507546,0.9397569,0.000279454,0.005829929,0.00004328984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991066,0.0009292496,0.003304591,0.0003120028,0.00009921704,0.00006773361,0.002313976,0.000268786,0.001638275],"genre_scores_gemma":[0.9699158,0.001321353,0.004310744,0.0003245344,0.0001396202,0.0003691489,0.00356956,0.0002495016,0.01979964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01001258,"threshold_uncertainty_score":0.03349537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02452482777941978,"score_gpt":0.2628346527063022,"score_spread":0.2383098249268824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}