{"id":"W48601634","doi":"10.1182/blood.v122.21.168.168","title":"Effective Treatment Of Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma With Autologous T Cells Genetically-Engineered To Express An Anti-CD19 Chimeric Antigen Receptor","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; CD19; Antigen; Immunology; Cyclophosphamide; Chimeric antigen receptor; T cell; Internal medicine; Immune system; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004070955,0.0004384065,0.000757664,0.0003088061,0.0002148689,0.0003678842,0.000298297,0.0002664042,0.001040882],"category_scores_gemma":[0.0002475839,0.0001558275,0.0003643627,0.0002200536,0.0003614238,0.0002767979,0.0002509266,0.0005990404,0.0003025024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773434,"about_ca_system_score_gemma":0.0002052886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205946,"about_ca_topic_score_gemma":0.0008906289,"domain_scores_codex":[0.9998647,0.00004372244,0.000008092466,0.0000219501,0.00002446211,0.00003709638],"domain_scores_gemma":[0.9998746,0.00003666879,0.00001863121,0.0000221589,0.000004289697,0.00004372087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02466553,0.01209649,0.01420589,0.000687884,0.0006053153,0.004511212,0.0005980716,0.007609297,0.5602908,0.001297764,0.002731695,0.3707],"study_design_scores_gemma":[0.05773325,0.3990169,0.1073442,0.0001447018,0.001534985,0.01463307,0.0002767505,0.01062643,0.3687841,0.001021671,0.03878823,0.00009574309],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939137,0.002926625,0.001049585,0.0001113155,0.00003391031,0.0001651051,0.00009425615,0.00005674534,0.001648647],"genre_scores_gemma":[0.9968355,0.001367654,0.0007982181,0.0000779779,0.0000371336,0.00007949412,0.0002504978,0.00001406881,0.0005394556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040882,"threshold_uncertainty_score":0.003482103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007627921460208917,"score_gpt":0.2469499303169068,"score_spread":0.2393220088566979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}