{"id":"W493550894","doi":"10.1038/npre.2011.6451.1","title":"Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGF&amp;x00DF;1 signaling to confer survival","year":2011,"lang":"en","type":"preprint","venue":"Nature Precedings","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"National Institutes of Health; University of Texas Southwestern Medical Center; National Aeronautics and Space Administration; U.S. Department of Energy","keywords":"Clusterin; Endogeny; Apoptosis; Luciferase; SMAD; Cancer research; Chemistry; Transgene; Transforming growth factor; Endocrinology; Internal medicine; Medicine; Biology; Cell culture; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0008539154,0.001597108,0.002210359,0.0007866685,0.0002426725,0.0002356185,0.001440262,0.003893309,0.001671295],"category_scores_gemma":[0.001366359,0.001255042,0.0005580536,0.0003671137,0.000240802,0.0002636276,0.004027408,0.006764724,0.000127559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004255243,"about_ca_system_score_gemma":0.0005474797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001480695,"about_ca_topic_score_gemma":0.00005635464,"domain_scores_codex":[0.992636,0.0004338336,0.001051701,0.002975213,0.001603839,0.001299361],"domain_scores_gemma":[0.9937014,0.0005132967,0.0008715818,0.002663078,0.0009495786,0.001301041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01099508,0.0004693149,0.003304114,0.002004639,0.0003645268,0.0005366225,0.007933188,0.00007804585,0.9626478,0.00002974328,0.01044308,0.001193844],"study_design_scores_gemma":[0.004360968,0.000580553,0.006546771,0.01682654,0.0007020093,0.0003480064,0.0006626003,0.00004530956,0.9652127,0.0003780385,0.002644503,0.001691982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809032,0.001099473,0.002050382,0.001078558,0.004076907,0.003622227,0.0001774016,0.0007950119,0.006196851],"genre_scores_gemma":[0.9835269,0.00006713739,0.0104413,0.001390317,0.001594511,0.0008385391,0.0004169475,0.0003784429,0.001345946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0148219,"threshold_uncertainty_score":0.9996777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05960462455686872,"score_gpt":0.3299463162250985,"score_spread":0.2703416916682297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}