{"id":"W52812077","doi":"10.1007/978-1-59745-205-2_8","title":"G Protein-Coupled Receptor Pharmacogenetics","year":2008,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Pharmacogenomics; G protein-coupled receptor; Pharmacogenetics; Receptor; Biology; Computational biology; Gene; 5-HT5A receptor; Single-nucleotide polymorphism; Genetics; Pharmacology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005585105,0.00109836,0.001237898,0.001430552,0.0002077113,0.0007311588,0.0009678247,0.001392442,0.005176907],"category_scores_gemma":[0.0007605767,0.0002154431,0.0004251759,0.001366152,0.0005534795,0.0009848891,0.0005840776,0.001662779,0.005745135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007125204,"about_ca_system_score_gemma":0.0006389496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007183432,"about_ca_topic_score_gemma":0.001051942,"domain_scores_codex":[0.9997336,0.00005459843,0.00002372556,0.00005404273,0.0001165005,0.00001748766],"domain_scores_gemma":[0.9998106,0.00009603866,0.00002028135,0.00001205755,0.00004624878,0.00001475584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004310611,0.00006564252,0.0001889402,0.002923148,0.00005272231,0.0004297548,0.00003433298,0.0004530936,0.001829638,0.009310671,0.04536725,0.9393017],"study_design_scores_gemma":[0.00001665579,0.00003962461,0.0004870314,0.0007411445,0.0000270951,0.002327674,0.00002368823,0.0001059663,0.0005085986,0.004185343,0.9915271,0.00001016819],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002983044,0.9835041,0.001902641,0.001232373,0.0006587834,0.00001809433,0.00004013595,0.00005117394,0.01229449],"genre_scores_gemma":[0.001954835,0.9876992,0.001753873,0.000902332,0.0005361718,0.0000263713,0.00006820158,0.000006392374,0.00705262],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005176907,"threshold_uncertainty_score":0.01731849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04669006543727119,"score_gpt":0.4281806402758226,"score_spread":0.3814905748385515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}