{"id":"W53169776","doi":"10.2174/1875397301005010062","title":"Chemical Biology of Lysine Demethylases","year":2011,"lang":"en","type":"article","venue":"Current Chemical Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Biology; Histone; Epigenetics; Methylation; Chromatin; Computational biology; Drug discovery; DNA methylation; Lysine; PRC2; Gene; Genetics; Gene expression; Histone H3; Bioinformatics; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129927,0.000152948,0.0001938568,0.00003432129,0.00001646573,0.000003490019,0.0002344899,0.0001770662,0.00004415015],"category_scores_gemma":[0.0001326083,0.000149075,0.0001256846,0.00007667645,0.0001671219,0.000001762045,0.0001692652,0.00009736203,0.000009255114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001495854,"about_ca_system_score_gemma":0.00005246837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000522054,"about_ca_topic_score_gemma":4.877721e-7,"domain_scores_codex":[0.9990463,0.00002698349,0.0003264828,0.0003183705,0.00006322527,0.000218586],"domain_scores_gemma":[0.9993427,0.00001567984,0.000129725,0.0003120301,0.00009944256,0.0001004385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005244547,0.0001375666,0.002310364,0.00001969404,0.00002689166,1.421349e-7,0.00004020927,0.000001000371,0.963774,0.0002860224,0.000061151,0.03329055],"study_design_scores_gemma":[0.0002916629,0.00006104552,0.0001504408,0.000005803008,0.0000264597,9.897875e-7,0.00000713686,0.00002389484,0.9745132,0.001307411,0.02344759,0.0001643972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872141,0.006759645,0.004729099,0.000008909071,0.0002119125,0.00009386146,0.00003414973,0.000009294141,0.0009389545],"genre_scores_gemma":[0.9916756,0.001118346,0.006614766,0.00001442101,0.0002556702,0.000009275383,0.0002799031,0.00002047008,0.000011619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03312615,"threshold_uncertainty_score":0.6079104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346055489264946,"score_gpt":0.2874570900031605,"score_spread":0.243996535110511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}