{"id":"W53169776","doi":"10.2174/1875397301005010062","title":"Chemical Biology of Lysine Demethylases","year":2011,"lang":"en","type":"article","venue":"Current Chemical Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Biology; Histone; Epigenetics; Methylation; Chromatin; Computational biology; Drug discovery; DNA methylation; Lysine; PRC2; Gene; Genetics; Gene expression; Histone H3; Bioinformatics; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346736,0.0004063294,0.0003217333,0.000302479,0.0003914812,0.0006440197,0.0004485646,0.0009563791,0.002134036],"category_scores_gemma":[0.000253008,0.0002415027,0.0002683465,0.0002187867,0.00070145,0.0008839694,0.0005563213,0.001342629,0.001259449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008934329,"about_ca_system_score_gemma":0.0004155157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004581847,"about_ca_topic_score_gemma":0.0003930606,"domain_scores_codex":[0.9998676,0.00002404735,0.000005894996,0.0000327475,0.00004370639,0.00002606743],"domain_scores_gemma":[0.9999228,0.00001748008,0.00001466574,0.000008485175,0.00002037529,0.00001629004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002107716,0.000200361,0.0008852615,0.00171392,0.00009909685,0.0008544381,0.0002371634,0.003583549,0.5702927,0.2651398,0.01255126,0.1442317],"study_design_scores_gemma":[0.00005340753,0.0005893487,0.00151818,0.00014354,0.00003807427,0.002155258,0.00009057253,0.002972506,0.3278017,0.06162179,0.6029654,0.00005032796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.10176,0.6625375,0.09527636,0.02261348,0.005005179,0.0001955499,0.000688129,0.0005333386,0.1113905],"genre_scores_gemma":[0.5741797,0.35186,0.0173819,0.004731916,0.001882861,0.0002347742,0.0006376586,0.00006238518,0.04902882],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002134036,"threshold_uncertainty_score":0.007139027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346055489264946,"score_gpt":0.2874570900031605,"score_spread":0.243996535110511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}