{"id":"W560863099","doi":"10.1016/j.addr.2015.04.019","title":"Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues","year":2015,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":246,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; Foundation for the National Institutes of Health","keywords":"Induced pluripotent stem cell; Regenerative medicine; Tissue engineering; Stem cell; Context (archaeology); Biology; Drug discovery; Neuroscience; Human studies; Cell biology; Medicine; Bioinformatics; Embryonic stem cell; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001425275,0.001198567,0.004025416,0.0003665989,0.0001739665,0.00008994559,0.001183977,0.0005448523,0.00001649624],"category_scores_gemma":[0.00003137859,0.001069476,0.00143226,0.000453714,0.0001096741,0.00002744195,0.0008310481,0.0008059299,0.0002320863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004173169,"about_ca_system_score_gemma":0.0002495341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003537236,"about_ca_topic_score_gemma":0.0000304915,"domain_scores_codex":[0.9937974,0.001207474,0.001742437,0.001565559,0.0005763585,0.001110811],"domain_scores_gemma":[0.9968289,0.00004392184,0.0006816308,0.001807291,0.0002365125,0.0004017517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001946512,0.0001212934,0.000009408399,0.02808109,0.0002747737,0.0001066221,0.00009015049,0.000134602,0.0652327,0.000004208287,0.004567415,0.9013582],"study_design_scores_gemma":[0.0004771861,0.00009739736,0.000001973266,0.007214807,0.0003236069,0.00001188268,0.00003936633,0.00000166606,0.006539004,0.000003209018,0.9842405,0.001049454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004208661,0.9905948,0.00001168399,0.000004946264,0.0003755423,0.003673932,0.0001339104,0.00005353529,0.0009429837],"genre_scores_gemma":[0.0003800342,0.9914433,0.000391656,0.00001639536,0.0004669622,0.0009785811,0.001757008,0.0002243641,0.004341725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979673,"threshold_uncertainty_score":0.9991755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998280507784691,"score_gpt":0.3259535188682983,"score_spread":0.2859707137904514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}