{"id":"W562875359","doi":"10.1210/en.2015-1418","title":"To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell","year":2015,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Montreal Clinical Research Institute","funders":"University of Toronto; Sunnybrook Research Institute; Canadian Diabetes Association","keywords":"Biology; Cre recombinase; Transgene; Gene; Gene expression; Genetically modified mouse; Cell; Transactivation; Cell biology; Recombinase; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057123,0.001249918,0.0008610635,0.001744913,0.000786798,0.001373799,0.001106857,0.00223904,0.009143998],"category_scores_gemma":[0.0004241572,0.000550562,0.001166058,0.0008281987,0.001272774,0.002060911,0.0007512093,0.004780181,0.003284314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048579,"about_ca_system_score_gemma":0.0004584739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003442378,"about_ca_topic_score_gemma":0.0008748802,"domain_scores_codex":[0.9994035,0.0001021157,0.00006490466,0.0001807654,0.0001563896,0.00009233436],"domain_scores_gemma":[0.9993205,0.0001006211,0.0001878686,0.0001288779,0.0000657823,0.0001963563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023103,0.0007001564,0.0009349629,0.0002540633,0.0000745831,0.0009255083,0.0001784973,0.0001361847,0.9626731,0.01077364,0.004128507,0.01819777],"study_design_scores_gemma":[0.001022223,0.005009925,0.008756207,0.0005153553,0.0007120393,0.01511797,0.0006138718,0.002786877,0.7022645,0.009273215,0.2537437,0.0001840623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7616155,0.0181523,0.1570921,0.00962504,0.005746004,0.001038351,0.00731669,0.003639495,0.03577444],"genre_scores_gemma":[0.6506758,0.02745951,0.1455641,0.00722761,0.001161084,0.002803272,0.008266577,0.002651456,0.1541906],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.009143998,"threshold_uncertainty_score":0.03058976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1232477209415392,"score_gpt":0.3099189058248877,"score_spread":0.1866711848833485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}