{"id":"W56457892","doi":"10.1182/blood.v122.21.144.144","title":"Co-Administration Of Gene-Modified CD4+ T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"CD8; Cytotoxic T cell; Biology; T cell; Immunotherapy; Adoptive cell transfer; Epitope; T-cell receptor; Interleukin 21; Cancer research; Immunology; Molecular biology; Antigen; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092342,0.0004631805,0.0004046828,0.000172472,0.00009045652,0.0002476422,0.0001632747,0.0002337096,0.0008353402],"category_scores_gemma":[0.00008018957,0.0001117784,0.0001946405,0.0001128663,0.0002166002,0.000176907,0.0001810807,0.0007718777,0.0002348654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138384,"about_ca_system_score_gemma":0.0001642504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002246561,"about_ca_topic_score_gemma":0.0002747167,"domain_scores_codex":[0.9998074,0.00003292546,0.00002126862,0.0000446435,0.00004008723,0.00005377536],"domain_scores_gemma":[0.9999363,0.000008735712,0.00001905276,0.00001033456,0.00000629947,0.00001924069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002344034,0.0001034772,0.0001231334,0.00002654635,0.000006088623,0.00002466008,0.00001224589,0.0001435576,0.9979137,0.00005230405,0.00002646238,0.001333589],"study_design_scores_gemma":[0.00004738257,0.001457848,0.001202073,0.000003237072,0.00003481349,0.0001399875,0.00001461392,0.0012014,0.9949575,0.00002136749,0.0009162987,0.00000350266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980606,0.0003539844,0.001005389,0.00003065026,0.00002025804,0.00002286622,0.00005885862,0.00004590559,0.0004014201],"genre_scores_gemma":[0.9974325,0.0002530757,0.001148478,0.00002363626,0.00001283873,0.00002914955,0.0001073015,0.00001147582,0.0009815042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008353402,"threshold_uncertainty_score":0.002794445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243319429196398,"score_gpt":0.2701206179103804,"score_spread":0.2576874236184164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}