{"id":"W567325059","doi":"10.1016/j.mce.2015.05.032","title":"In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases","year":2015,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital du Saint-Sacrement; Université Laval","funders":"Canadian Institutes of Health Research; China Scholarship Council; Academy of Finland","keywords":"Aromatase; Paracrine signalling; MCF-7; Stromal cell; Intracrine; Cancer cell; Steroid sulfatase; Cell growth; Cancer research; Chemistry; Cell culture; Sulfatase; Cell biology; Biology; Endocrinology; Internal medicine; Steroid; Cancer; Enzyme; Biochemistry; Hormone; Breast cancer; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971046,0.0004171795,0.0003420085,0.0002340952,0.0003169018,0.0003917636,0.0001951813,0.0002273325,0.002018107],"category_scores_gemma":[0.0001896809,0.0002155935,0.0004115688,0.0002105528,0.00019642,0.0001902279,0.0002572231,0.0004584837,0.0005724909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365557,"about_ca_system_score_gemma":0.000221344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002477226,"about_ca_topic_score_gemma":0.004146927,"domain_scores_codex":[0.9996139,0.0001049666,0.0000339111,0.00004488825,0.00008989375,0.0001124056],"domain_scores_gemma":[0.9998086,0.00009308047,0.00002440714,0.00002339511,0.00002142082,0.00002906131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606707,0.00006415154,0.0005327861,0.00003992311,0.00001344587,0.0001090937,0.00004576967,0.00004847088,0.9978358,0.0001065866,0.00007781096,0.0008655075],"study_design_scores_gemma":[0.00001453723,0.0002949403,0.004739042,0.000005243238,0.00002537456,0.0001690884,0.00008522137,0.0003289899,0.9924678,0.00003790247,0.001828281,0.000003588559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990492,0.003052437,0.00133991,0.0001707869,0.0001223216,0.00002258672,0.0004456952,0.0000409595,0.004313168],"genre_scores_gemma":[0.9910802,0.001730337,0.001445803,0.0000971453,0.00004757812,0.00003064764,0.001014382,0.00001502332,0.004538813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477226,"threshold_uncertainty_score":0.00675118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008819800382217214,"score_gpt":0.2392723473936543,"score_spread":0.2304525470114371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}