{"id":"W58114546","doi":"10.1593/neo.91298","title":"A Mutant of Hepatitis B Virus X Protein (HBxΔ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"HBx; Downregulation and upregulation; Biology; Fatty acid synthase; Cell growth; Small interfering RNA; Kinase; Cerulenin; Cancer research; Signal transduction; Molecular biology; Chemistry; Cell biology; Cell culture; Biochemistry; Transfection; Fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001248873,0.0002628222,0.0003034691,0.00004297011,0.00009952427,0.00003588885,0.0001657573,0.0002489551,0.00004031763],"category_scores_gemma":[0.0001368847,0.0002486052,0.0001051807,0.0001130961,0.0002168578,0.0000180332,0.0001399861,0.0002232627,0.000007334143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001000747,"about_ca_system_score_gemma":0.0001663628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399316,"about_ca_topic_score_gemma":0.00206478,"domain_scores_codex":[0.9986699,0.00006031366,0.0002849692,0.0004881818,0.0001687736,0.0003278721],"domain_scores_gemma":[0.9991387,0.00001632169,0.000175842,0.0003594892,0.0001705898,0.0001390905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568678,0.0001522235,0.001460928,0.000122266,0.00004370957,0.000002147296,0.0004624025,2.180125e-7,0.9950869,0.0001872231,0.0006452058,0.001679908],"study_design_scores_gemma":[0.0009711299,0.0003227241,0.002858092,0.00005371849,0.00004675025,0.00004953512,0.00007512885,0.00003064006,0.989015,0.0001882227,0.006109057,0.0002800243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950748,0.00179295,0.0003838813,0.00007586367,0.000967308,0.0005956799,0.0002684639,0.00001864161,0.0008224039],"genre_scores_gemma":[0.9936959,0.0009006438,0.003134262,0.0001341887,0.001783803,0.00007705404,0.00007143722,0.00004071392,0.0001620072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006071924,"threshold_uncertainty_score":0.9999966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005377077600440403,"score_gpt":0.2146597399281023,"score_spread":0.2092826623276619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}