{"id":"W58114546","doi":"10.1593/neo.91298","title":"A Mutant of Hepatitis B Virus X Protein (HBxΔ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"HBx; Downregulation and upregulation; Biology; Fatty acid synthase; Cell growth; Small interfering RNA; Kinase; Cerulenin; Cancer research; Signal transduction; Molecular biology; Chemistry; Cell biology; Cell culture; Biochemistry; Transfection; Fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297867,0.0003551067,0.0001853381,0.0001286157,0.0001008729,0.0001222159,0.000128227,0.0001853899,0.00104911],"category_scores_gemma":[0.0000652765,0.0001180144,0.0002248689,0.00009415666,0.0002068313,0.00009974638,0.0001475074,0.0003393714,0.0002207884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420373,"about_ca_system_score_gemma":0.0001236106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472927,"about_ca_topic_score_gemma":0.0003422723,"domain_scores_codex":[0.9998997,0.00002432436,0.00001266989,0.00001682702,0.00002845593,0.00001801838],"domain_scores_gemma":[0.9999286,0.00001384481,0.00002236965,0.000008180046,0.00000420786,0.00002273724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001759301,0.0000455304,0.0001528554,0.00002488302,0.000004531331,0.00004440944,0.00000671713,0.00004496083,0.9988859,0.00005624099,0.00002140861,0.0005366248],"study_design_scores_gemma":[0.00009290007,0.00121124,0.00447289,0.000009254561,0.00002111307,0.0003968029,0.00003101931,0.002213749,0.9897692,0.00004433479,0.001730407,0.000007042553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984066,0.0003362503,0.0007332398,0.00004133954,0.00001607238,0.00001664742,0.00009064977,0.00003219208,0.0003270388],"genre_scores_gemma":[0.996411,0.0002996181,0.001571286,0.00003437381,0.000006962343,0.00003186874,0.0003026426,0.000009562784,0.001332558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104911,"threshold_uncertainty_score":0.003509581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005377077600440403,"score_gpt":0.2146597399281023,"score_spread":0.2092826623276619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}