{"id":"W582011671","doi":"10.1371/journal.pone.0126466","title":"Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways","year":2015,"lang":"es","type":"article","venue":"PLoS ONE","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation","keywords":"PRC2; Biology; H3K4me3; Immune system; Cytokine; Cancer research; Cancer cell; Epigenetics; Cancer; Bivalent chromatin; Cell biology; EZH2; Immunology; Chromatin remodeling; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000185136,0.0003096526,0.0003691941,0.00004630467,0.00006828668,0.00007003888,0.0003154061,0.0003299629,0.00004956268],"category_scores_gemma":[0.0001527143,0.000314134,0.0001069393,0.0001326413,0.00005202874,0.000005104905,0.000240264,0.0001902737,0.0002178149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221377,"about_ca_system_score_gemma":0.0003933002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003316975,"about_ca_topic_score_gemma":0.0000985303,"domain_scores_codex":[0.9980636,0.00005291711,0.0003359397,0.0006204941,0.0004544177,0.0004726165],"domain_scores_gemma":[0.9983826,0.00001799347,0.0001186834,0.0006430898,0.0004001982,0.0004374248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001838444,0.0009055712,0.001463286,0.000221275,0.0003067381,0.000004778597,0.0002700603,0.002178393,0.987674,0.0000124254,0.005546913,0.001232695],"study_design_scores_gemma":[0.001220505,0.000472923,0.0001514949,0.0004218109,0.0001337117,0.000001167822,0.00008723306,0.007152603,0.9771796,0.00004010355,0.01267255,0.0004662652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923907,0.004201302,0.0003814468,0.0006535319,0.0002395793,0.0004523533,0.0005222447,0.000044879,0.001113987],"genre_scores_gemma":[0.9902737,0.002213529,0.003403919,0.0007959545,0.001298455,0.0001167459,0.0001160154,0.00007793042,0.001703736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01049439,"threshold_uncertainty_score":0.9999311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07043377326380526,"score_gpt":0.2604834240724269,"score_spread":0.1900496508086216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}