{"id":"W582011671","doi":"10.1371/journal.pone.0126466","title":"Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways","year":2015,"lang":"es","type":"article","venue":"PLoS ONE","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation","keywords":"PRC2; Biology; H3K4me3; Immune system; Cytokine; Cancer research; Cancer cell; Epigenetics; Cancer; Bivalent chromatin; Cell biology; EZH2; Immunology; Chromatin remodeling; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212896,0.0003298721,0.0002859028,0.000151903,0.0001543637,0.0004337119,0.0002054936,0.0002659002,0.002048298],"category_scores_gemma":[0.0001352991,0.0001599841,0.0002485586,0.0001340817,0.0002223455,0.0002706683,0.0003639456,0.0005445646,0.0007070542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342354,"about_ca_system_score_gemma":0.0001791801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006139872,"about_ca_topic_score_gemma":0.001009039,"domain_scores_codex":[0.9998796,0.0000113152,0.000008968655,0.00003437413,0.00003211976,0.00003372214],"domain_scores_gemma":[0.999926,0.00001062858,0.00001556197,0.00002252348,0.000008374183,0.00001690084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004776883,0.000006930081,0.0004832604,0.00002935661,0.00001115986,0.00005710642,0.00001114418,0.0001089763,0.996905,0.0004010798,0.0001452057,0.001792992],"study_design_scores_gemma":[0.0000157965,0.0001082692,0.005525582,0.000003311619,0.00001685306,0.0003739488,0.00001880674,0.001247752,0.9835065,0.0001908594,0.008986131,0.000006158509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697954,0.00547652,0.01529043,0.0004753798,0.0001389377,0.00006018788,0.001117087,0.0006948316,0.006951159],"genre_scores_gemma":[0.9934433,0.0007501638,0.001857277,0.0001312207,0.00001242705,0.00002035005,0.0005399122,0.00003040369,0.003214959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048298,"threshold_uncertainty_score":0.00685221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07043377326380526,"score_gpt":0.2604834240724269,"score_spread":0.1900496508086216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}