{"id":"W58822501","doi":"10.1007/978-1-4939-0888-2_24","title":"Analyzing RB and E2F During the G1–S Transition","year":2014,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Occupational Cancer Research Centre; Western University; Cancer Care Ontario","funders":"","keywords":"E2F; Retinoblastoma protein; Regulator; Transcription factor; Cyclin-dependent kinase; Transcription (linguistics); Cell biology; Restriction point; Cancer research; E2F1; Cell cycle; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001234531,0.0001387063,0.0002895509,0.0001638028,0.00006013936,0.000008428787,0.00007895229,0.0001893385,0.00001778899],"category_scores_gemma":[0.000369185,0.0001053219,0.00008577196,0.0002630986,0.0001544582,0.00001326249,0.00004519201,0.0003472109,0.000002809111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005169409,"about_ca_system_score_gemma":0.00002297908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005361855,"about_ca_topic_score_gemma":0.00001316249,"domain_scores_codex":[0.9980593,0.001055653,0.0002354138,0.0003313772,0.00005835776,0.0002599415],"domain_scores_gemma":[0.9993831,0.0001326497,0.00005349329,0.0003392181,0.00002998814,0.0000615642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005487797,0.00001614608,0.001018695,0.00003418922,0.00004224196,0.00002873633,0.0001819336,0.00007791851,0.9696694,0.001021588,0.000002634919,0.02785162],"study_design_scores_gemma":[0.003539045,0.0004906695,0.01281558,0.0001499228,0.0002330686,0.0005562835,0.00009806472,0.006881016,0.9616332,0.007453154,0.005769489,0.0003804871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2944209,0.001224059,0.7024826,0.0008547837,0.000104626,0.0001941632,0.000001230349,0.00002792641,0.0006896728],"genre_scores_gemma":[0.5988486,0.0001380124,0.3998671,0.0009413818,0.00008650518,0.00003893031,0.00001279677,0.00003365353,0.00003296043],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.3044278,"threshold_uncertainty_score":0.4294901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321542520334991,"score_gpt":0.3569478812966613,"score_spread":0.3437324560933114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}