{"id":"W591410430","doi":"10.1182/blood.v124.21.4986.4986","title":"Eculizumab Inhibits Thrombotic Microangiopathy and Improves Renal Function in Pediatric Patients with Atypical Hemolytic Uremic Syndrome: 1-Year Update","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Eculizumab; Thrombotic microangiopathy; Medicine; Atypical hemolytic uremic syndrome; Gastroenterology; Internal medicine; Renal function; Immunology; Complement system; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003531954,0.0008349832,0.00220155,0.0008436441,0.0002132557,0.001518818,0.0008558485,0.001364586,0.001356929],"category_scores_gemma":[0.002834128,0.0003417171,0.001060947,0.0008798538,0.0004593738,0.001132511,0.0003438401,0.002242416,0.0004447378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006233274,"about_ca_system_score_gemma":0.0008985196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004529287,"about_ca_topic_score_gemma":0.001283601,"domain_scores_codex":[0.9994746,0.0001829509,0.0001114764,0.00005845827,0.0001113636,0.00006112374],"domain_scores_gemma":[0.9970131,0.001634449,0.0005482779,0.00006237321,0.0005028161,0.000238896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.008974428,0.001318225,0.004718462,0.0199927,0.002387052,0.0005851048,0.0002489816,0.001060027,0.003913817,0.001706767,0.0354169,0.9196776],"study_design_scores_gemma":[0.01798588,0.04468868,0.06094091,0.03250462,0.01477963,0.007128197,0.0005046797,0.003176333,0.005453771,0.002146219,0.8104363,0.0002548056],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01286935,0.9831015,0.0003198051,0.001838318,0.0003961831,0.00005069005,0.000175369,0.0000299694,0.00121869],"genre_scores_gemma":[0.05670068,0.9341706,0.001191177,0.00415672,0.001930468,0.0001742552,0.0007052551,0.00001954012,0.0009512894],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003531954,"threshold_uncertainty_score":0.01867896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003369332402540062,"score_gpt":0.1748863785697887,"score_spread":0.1715170461672487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}