{"id":"W591410430","doi":"10.1182/blood.v124.21.4986.4986","title":"Eculizumab Inhibits Thrombotic Microangiopathy and Improves Renal Function in Pediatric Patients with Atypical Hemolytic Uremic Syndrome: 1-Year Update","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Eculizumab; Thrombotic microangiopathy; Medicine; Atypical hemolytic uremic syndrome; Gastroenterology; Internal medicine; Renal function; Immunology; Complement system; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234554,0.0001977593,0.0002806098,0.0001562462,0.00008674304,0.00001966972,0.0001171329,0.0001225312,0.00008364546],"category_scores_gemma":[0.00004815148,0.0001650505,0.00004188796,0.0001695212,0.00007838506,0.00009364219,0.00009922594,0.0001629415,0.0001853801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002390409,"about_ca_system_score_gemma":0.00003558846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001151838,"about_ca_topic_score_gemma":0.00002776841,"domain_scores_codex":[0.9987713,0.0001563526,0.0002916332,0.0003889887,0.00005824814,0.0003335334],"domain_scores_gemma":[0.9994947,0.00006042918,0.0001165542,0.0002465912,0.00004380174,0.00003794623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005265342,0.0009419947,0.9851583,0.0001349356,0.0001265064,0.000007911997,0.00007570713,0.000002218474,0.01196368,0.0001757626,0.0005171317,0.000369362],"study_design_scores_gemma":[0.008920755,0.0008227405,0.9877924,0.00007904017,0.0003288285,0.00006556289,0.00002411202,0.000002341671,0.001457522,0.000119564,0.0001495147,0.0002376544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982271,0.0009774277,0.00003362292,0.00002966791,0.0001751512,0.000419982,0.000022736,0.00005734827,0.00005699735],"genre_scores_gemma":[0.9996014,0.00001221471,0.00005090731,0.00005697537,0.00003191736,0.00002757627,0.0001645366,0.00002153435,0.0000329433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01050616,"threshold_uncertainty_score":0.6730565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003369332402540062,"score_gpt":0.1748863785697887,"score_spread":0.1715170461672487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}