{"id":"W593268778","doi":"","title":"BUTYRATE REDUCES FREE CHOLESTEROL ACCUMULATION IN NIEMANN-PICK DISEASE TYPE C1 CELLS (NOVA SCOTIA FORM) THROUGH THE INDUCTION OF ACID SPHINGOMYELINASE","year":2012,"lang":"en","type":"article","venue":"Institutional Repositories DataBase (IRDB)","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"NPC1; Acid sphingomyelinase; Butyrate; Butyric acid; Niemann–Pick disease, type C; Sphingomyelin phosphodiesterase; Intracellular; Sphingomyelin; Chemistry; Sandhoff disease; Lymphoblast; Biochemistry; Cholesterol; Biology; Enzyme; Cell culture","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004690441,0.0002527057,0.0003009232,0.0001583978,0.0002722793,0.00006610532,0.0003381694,0.0001223984,0.00007297777],"category_scores_gemma":[0.00123633,0.0001928374,0.00009809143,0.0007165118,0.0004771151,0.002179668,0.0003095901,0.0004469846,0.00006840478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486195,"about_ca_system_score_gemma":0.0006766241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002814753,"about_ca_topic_score_gemma":0.0002880483,"domain_scores_codex":[0.9974374,0.0001148995,0.0006032715,0.0003793708,0.001011839,0.0004532284],"domain_scores_gemma":[0.9980981,0.00008306816,0.0002262368,0.00090381,0.0004616891,0.000227047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00508362,0.002588685,0.3558013,0.001161967,0.0002939081,0.0002927661,0.004120445,0.001260305,0.6085478,0.01323216,0.005737234,0.001879757],"study_design_scores_gemma":[0.004877286,0.0003784323,0.4286167,0.001329676,0.0003278982,0.0002854497,0.001316335,0.0004791608,0.5419377,0.0008454014,0.01889238,0.0007136234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929179,0.001637008,0.0005230941,0.0008366561,0.002301519,0.000796998,0.0002506977,0.00004849682,0.0006876396],"genre_scores_gemma":[0.9967629,0.00009313427,0.000814482,0.0001267876,0.001240453,0.00002996542,0.0007065341,0.00002496274,0.000200806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07281534,"threshold_uncertainty_score":0.7863679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07164926114461254,"score_gpt":0.3501002809974264,"score_spread":0.2784510198528138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}