{"id":"W593268778","doi":"","title":"BUTYRATE REDUCES FREE CHOLESTEROL ACCUMULATION IN NIEMANN-PICK DISEASE TYPE C1 CELLS (NOVA SCOTIA FORM) THROUGH THE INDUCTION OF ACID SPHINGOMYELINASE","year":2012,"lang":"en","type":"article","venue":"Institutional Repositories DataBase (IRDB)","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"NPC1; Acid sphingomyelinase; Butyrate; Butyric acid; Niemann–Pick disease, type C; Sphingomyelin phosphodiesterase; Intracellular; Sphingomyelin; Chemistry; Sandhoff disease; Lymphoblast; Biochemistry; Cholesterol; Biology; Enzyme; Cell culture","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129148,0.0005328453,0.0004746551,0.0001959398,0.0002098163,0.000248882,0.0002269499,0.0002957475,0.0009639568],"category_scores_gemma":[0.0001522499,0.0001840301,0.0002797348,0.0001975642,0.000190081,0.0001000035,0.0001905394,0.0005679221,0.0003508369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005433547,"about_ca_system_score_gemma":0.0005214852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02525312,"about_ca_topic_score_gemma":0.02869287,"domain_scores_codex":[0.999833,0.00002708656,0.00002334201,0.00002119784,0.00005397131,0.00004132602],"domain_scores_gemma":[0.9998305,0.00003109541,0.00003183103,0.00002303084,0.00003205111,0.00005144252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004442092,0.00004420299,0.0002524513,0.00004937629,0.000005323492,0.00007615808,0.00001863275,0.00003663267,0.9985107,0.000008064508,0.00006031959,0.0004939354],"study_design_scores_gemma":[0.0001650757,0.001903094,0.04585062,0.00002223491,0.00004440809,0.0003598028,0.0001585402,0.001098993,0.946588,0.00002499025,0.003767709,0.0000164417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954383,0.002033301,0.0002565062,0.0001580771,0.00005886981,0.00003972026,0.0009525783,0.00003744038,0.001025231],"genre_scores_gemma":[0.9921545,0.001375566,0.000903599,0.00009697924,0.00001140832,0.00004795558,0.001471501,0.00001880963,0.00391974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02525312,"threshold_uncertainty_score":0.05021226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07164926114461254,"score_gpt":0.3501002809974264,"score_spread":0.2784510198528138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}