{"id":"W596660519","doi":"10.1371/journal.ppat.1004970","title":"Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; National Institute of Allergy and Infectious Diseases; NYU Langone Medical Center; National Institute of General Medical Sciences; Burroughs Wellcome Fund","keywords":"Leukocidin; Staphylococcus aureus; Microbiology; Panton–Valentine leukocidin; Intracellular; Extracellular; Host (biology); Intracellular parasite; Chemistry; Biology; Bacteria; Cell biology; Methicillin-resistant Staphylococcus aureus; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057277,0.0002341354,0.0001648611,0.000136061,0.00012607,0.0002740332,0.00004975143,0.0002544042,0.0007930166],"category_scores_gemma":[0.00009464908,0.00007814351,0.0001862283,0.0000851713,0.0001278312,0.0001252621,0.0002181349,0.0002650319,0.0003794722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453141,"about_ca_system_score_gemma":0.000147356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003947254,"about_ca_topic_score_gemma":0.00040195,"domain_scores_codex":[0.9998673,0.00003267873,0.00001560713,0.00002157894,0.00002499727,0.00003778448],"domain_scores_gemma":[0.9999579,0.000005178931,0.00001367472,0.000005053492,0.000006092049,0.00001200615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002014212,0.0000157932,0.0004090161,0.00005416469,0.000004004328,0.0001027914,0.00002437771,0.00002692362,0.9975219,0.00004063098,0.00004110957,0.001557765],"study_design_scores_gemma":[0.00006616418,0.001551845,0.02829275,0.00003671132,0.00002688574,0.002016491,0.0001375077,0.001059266,0.9611624,0.0002206468,0.005418014,0.0000113201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906687,0.004704926,0.002897334,0.0001557331,0.00002149384,0.0000236072,0.0002623715,0.00006392645,0.00120204],"genre_scores_gemma":[0.995891,0.001426903,0.0013126,0.0001055967,0.000009142708,0.0000275047,0.0002219541,0.000004301364,0.001001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007930166,"threshold_uncertainty_score":0.002652884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098644423876823,"score_gpt":0.2291978141387397,"score_spread":0.2082113698999715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}