{"id":"W596660519","doi":"10.1371/journal.ppat.1004970","title":"Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; National Institute of Allergy and Infectious Diseases; NYU Langone Medical Center; National Institute of General Medical Sciences; Burroughs Wellcome Fund","keywords":"Leukocidin; Staphylococcus aureus; Microbiology; Panton–Valentine leukocidin; Intracellular; Extracellular; Host (biology); Intracellular parasite; Chemistry; Biology; Bacteria; Cell biology; Methicillin-resistant Staphylococcus aureus; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003279924,0.0003931067,0.0003416271,0.00009469633,0.0002117209,0.00008150948,0.0003279861,0.0003522156,0.00006832589],"category_scores_gemma":[0.0001311537,0.0003968531,0.0001517043,0.00008413779,0.0001836898,0.00001730561,0.0002613331,0.0002258848,0.00007850093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003441989,"about_ca_system_score_gemma":0.00009862032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006186767,"about_ca_topic_score_gemma":0.00003149374,"domain_scores_codex":[0.9979627,0.0001333345,0.0004082351,0.0006428423,0.0002778041,0.0005750607],"domain_scores_gemma":[0.9986814,0.00001458724,0.0001611138,0.0006821594,0.0001996384,0.0002610585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008213684,0.000154216,0.003857389,0.00003110205,0.000149315,0.00004730254,0.0005040199,0.00001186707,0.9928355,0.00006510359,0.0009076496,0.001354378],"study_design_scores_gemma":[0.001228953,0.0004535178,0.001712,0.00001914589,0.0001007676,0.00001042505,0.0005235633,0.0001617435,0.9805096,0.0002828451,0.01442042,0.0005770314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906791,0.007088164,0.0005671733,0.000166054,0.0001449361,0.0004133032,0.00007653241,0.00004871413,0.0008160431],"genre_scores_gemma":[0.9957793,0.0002809035,0.0009278322,0.0002227529,0.000290638,0.00005360731,0.0003584948,0.00007655071,0.002009883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01351277,"threshold_uncertainty_score":0.9998483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098644423876823,"score_gpt":0.2291978141387397,"score_spread":0.2082113698999715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}