{"id":"W602792198","doi":"10.1371/journal.ppat.1004938","title":"IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Johns Hopkins University","keywords":"CD11c; Leishmania donovani; Cytotoxic T cell; CD8; Inflammation; Biology; Cell biology; Immunology; Immune system; T cell; Leishmania major; Dendritic cell; Leishmania; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002600937,0.0002107821,0.0001861349,0.0001501339,0.0001198581,0.000184484,0.0001784352,0.0002540624,0.001242749],"category_scores_gemma":[0.0001236058,0.00009779781,0.0001998953,0.00008229954,0.0002552183,0.0001804783,0.0001783781,0.0005318799,0.0001999868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967275,"about_ca_system_score_gemma":0.0001649632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002144528,"about_ca_topic_score_gemma":0.0002446936,"domain_scores_codex":[0.9998534,0.00003117588,0.00001177526,0.00002172077,0.00002442483,0.00005746495],"domain_scores_gemma":[0.9999206,0.000008179403,0.00002511826,0.00001024033,0.000009118981,0.00002668379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002835578,0.00004039664,0.0002305324,0.00003372724,0.000003214805,0.00002629131,0.00001021472,0.00004761958,0.99805,0.0000943285,0.00002587146,0.00115433],"study_design_scores_gemma":[0.00004124327,0.0006625237,0.005697402,0.00001052806,0.00001887592,0.0003257365,0.0000347664,0.0007151167,0.9907647,0.00011303,0.001612124,0.000003836562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950724,0.001210094,0.002630972,0.000127363,0.0000213692,0.00001963607,0.0001322274,0.00004084664,0.0007450818],"genre_scores_gemma":[0.9973518,0.0003482484,0.001113835,0.00005431745,0.000009091678,0.00002101937,0.0001627802,0.000006166033,0.000932843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242749,"threshold_uncertainty_score":0.004157424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0346544755485796,"score_gpt":0.2575950907494793,"score_spread":0.2229406152008997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}