{"id":"W605291159","doi":"10.1371/journal.pmed.1001841","title":"Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study","year":2015,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; University College London Hospitals NHS Foundation Trust; Helmholtz Zentrum München; National Center for Advancing Translational Sciences; Economic and Social Research Council; AstraZeneca; European Commission; Genentech; National Institutes of Health; Heinz Nixdorf Stiftung; Dana Foundation; H. Lundbeck A/S; Medical Research Council; National Institute of Child Health and Human Development; Eli Lilly and Company; Hersenstichting; King's College London; Universitat de Barcelona; Canadian Institutes of Health Research; Alzheimer's Society; Stichting MS Research; Medpace; Bundesministerium für Bildung und Forschung; Newcastle University; University of Cambridge; National Institute on Aging; National Institute for Health and Care Research; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Alfried Krupp von Bohlen und Halbach-Stiftung; National Cancer Institute; Lundbeckfonden; Howard Hughes Medical Institute; Cardiff University; Alzheimer's Research Trust; Synarc; South London and Maudsley NHS Foundation Trust; F. Hoffmann-La Roche; Menzies Centre for Australian Studies, King's College London, University of London; U.S. Department of Veterans Affairs; Elan; Office of Research and Development; GlaxoSmithKline; Pfizer; Novartis; Wellcome Trust; North Bristol NHS Trust; Bristol-Myers Squibb; Juvenile Diabetes Research Foundation International; Eisai","keywords":"Mendelian randomization; Alzheimer's disease; Disease; Medicine; Dementia; Gerontology; Bioinformatics; Biology; Internal medicine; Genetics; Gene; Genetic variants; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007213231,0.0001424804,0.0003243413,0.00005596589,0.0001273396,0.000008819413,0.00008818847,0.0000967185,0.00001619272],"category_scores_gemma":[0.001967832,0.0001074079,0.0000357733,0.00009629428,0.00005807284,0.000004215938,0.00006112294,0.00007869413,0.000004187084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001782996,"about_ca_system_score_gemma":0.00006849153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006008081,"about_ca_topic_score_gemma":0.00003495062,"domain_scores_codex":[0.9986814,0.0003166088,0.0003214587,0.0002852442,0.0001992295,0.0001960071],"domain_scores_gemma":[0.9990702,0.0000753652,0.0002101327,0.0002123913,0.0001741434,0.0002577448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004609281,0.0001096711,0.9944945,0.000001247763,0.0004599266,5.895107e-7,0.0003067152,0.0005648874,0.000423018,0.000005214492,0.003344428,0.0002437154],"study_design_scores_gemma":[0.00652266,0.0006442743,0.9871917,0.00000872616,0.001495012,3.377409e-7,0.0008468992,0.001271799,0.000173279,0.0004587902,0.00117637,0.0002101633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940597,0.001036197,0.003183739,0.0006573236,0.0001113143,0.0004697661,0.0001072655,0.00001744715,0.0003572612],"genre_scores_gemma":[0.9980475,0.0001360818,0.000308145,0.00007645779,0.000375458,0.00002476269,0.0008289614,0.00001652803,0.0001861469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007302805,"threshold_uncertainty_score":0.4379969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163435921687169,"score_gpt":0.2999796246418735,"score_spread":0.2483452654250018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}