{"id":"W605291159","doi":"10.1371/journal.pmed.1001841","title":"Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study","year":2015,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; University College London Hospitals NHS Foundation Trust; Helmholtz Zentrum München; National Center for Advancing Translational Sciences; Economic and Social Research Council; AstraZeneca; European Commission; Genentech; National Institutes of Health; Heinz Nixdorf Stiftung; Dana Foundation; H. Lundbeck A/S; Medical Research Council; National Institute of Child Health and Human Development; Eli Lilly and Company; Hersenstichting; King's College London; Universitat de Barcelona; Canadian Institutes of Health Research; Alzheimer's Society; Stichting MS Research; Medpace; Bundesministerium für Bildung und Forschung; Newcastle University; University of Cambridge; National Institute on Aging; National Institute for Health and Care Research; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Alfried Krupp von Bohlen und Halbach-Stiftung; National Cancer Institute; Lundbeckfonden; Howard Hughes Medical Institute; Cardiff University; Alzheimer's Research Trust; Synarc; South London and Maudsley NHS Foundation Trust; F. Hoffmann-La Roche; Menzies Centre for Australian Studies, King's College London, University of London; U.S. Department of Veterans Affairs; Elan; Office of Research and Development; GlaxoSmithKline; Pfizer; Novartis; Wellcome Trust; North Bristol NHS Trust; Bristol-Myers Squibb; Juvenile Diabetes Research Foundation International; Eisai","keywords":"Mendelian randomization; Alzheimer's disease; Disease; Medicine; Dementia; Gerontology; Bioinformatics; Biology; Internal medicine; Genetics; Gene; Genetic variants; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03698925,0.001187425,0.001582366,0.0009502152,0.0008101167,0.0009291591,0.001376884,0.001191396,0.002069623],"category_scores_gemma":[0.07152964,0.0007406185,0.001914668,0.001320332,0.001070997,0.0006384411,0.0006752699,0.001022821,0.0002558644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005514638,"about_ca_system_score_gemma":0.0009713808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003670441,"about_ca_topic_score_gemma":0.001795048,"domain_scores_codex":[0.9507399,0.042059,0.001392773,0.003691301,0.001651639,0.0004653134],"domain_scores_gemma":[0.9613853,0.02503396,0.003926557,0.008217557,0.0009402098,0.0004964397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05398453,0.001766013,0.8181773,0.0006483233,0.02813049,0.003305353,0.001450377,0.01296803,0.005544327,0.01905441,0.004614451,0.05035641],"study_design_scores_gemma":[0.03854546,0.01947095,0.4869023,0.0004742539,0.03374192,0.01335804,0.0006433981,0.3362373,0.004183648,0.05234308,0.01354522,0.0005545446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8669226,0.001689401,0.1266402,0.0006134776,0.0002170565,0.001360229,0.0009494332,0.0003272633,0.001280484],"genre_scores_gemma":[0.9680265,0.0002360492,0.0298001,0.0002660919,0.00007122356,0.0007768287,0.0004173929,0.00004512676,0.0003607081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03698925,"threshold_uncertainty_score":0.1956202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05163435921687169,"score_gpt":0.2999796246418735,"score_spread":0.2483452654250018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}