{"id":"W610485528","doi":"10.1182/blood-2014-12-618678","title":"Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; Sunnybrook Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Stromal cell; Toll-like receptor; Signal transduction; Immunology; Cancer research; Biology; Leukemia; Interleukin-1 receptor; Receptor; Cell biology; Interleukin 3; Cytokine; Interleukin; Immune system; Antigen-presenting cell; T cell; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506192,0.0001980059,0.0002498023,0.0001779702,0.0001298825,0.0003997901,0.00009990087,0.0001137125,0.001562187],"category_scores_gemma":[0.0001069475,0.0001163413,0.0001815967,0.0001256798,0.0001668154,0.0001034368,0.0002001436,0.0004348273,0.0005970047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299578,"about_ca_system_score_gemma":0.0002406197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002802,"about_ca_topic_score_gemma":0.0003500191,"domain_scores_codex":[0.9998611,0.00003170056,0.00001760727,0.00001630605,0.00003335631,0.00003979896],"domain_scores_gemma":[0.999917,0.00001652074,0.0000239233,0.00001105366,0.000008530369,0.0000228447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003426996,0.00008073205,0.0003942015,0.00002735247,0.000004921297,0.00004607511,0.00002405606,0.00004633514,0.9971151,0.00009410507,0.00007164806,0.001752694],"study_design_scores_gemma":[0.0000577471,0.0006171532,0.002276009,0.000004735141,0.00001649161,0.0002196607,0.00003671361,0.0007114254,0.9921027,0.00004017124,0.003914761,0.000002525274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959889,0.001306637,0.00096532,0.00008994662,0.00002749471,0.00002145743,0.0002035638,0.00006526268,0.001331278],"genre_scores_gemma":[0.9966589,0.0006863235,0.0009576537,0.00005194965,0.00001096585,0.00002950886,0.0003459522,0.00001512764,0.001243615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562187,"threshold_uncertainty_score":0.005226016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03197391298599731,"score_gpt":0.2929792186043396,"score_spread":0.2610053056183423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}