{"id":"W611905905","doi":"10.2119/molmed.2015.00139","title":"A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo","year":2015,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Chronic lymphocytic leukemia; Peroxisome proliferator-activated receptor; Biology; Cancer research; Apoptosis; Downregulation and upregulation; Cell growth; Cell biology; Receptor; Peroxisome; Leukemia; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167987,0.0003499423,0.0004520708,0.0003419633,0.0002110214,0.0002055591,0.0001714754,0.0002362606,0.002207809],"category_scores_gemma":[0.00009024949,0.0001341827,0.000167311,0.0002579936,0.0002077056,0.0001379,0.0001536869,0.0007410457,0.0004346102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294356,"about_ca_system_score_gemma":0.0002755327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004785611,"about_ca_topic_score_gemma":0.001727182,"domain_scores_codex":[0.9999006,0.00001828098,0.000008798657,0.00001810716,0.00002910292,0.00002512463],"domain_scores_gemma":[0.9999495,0.00001277693,0.00001187454,0.000005959862,0.000006909645,0.00001295341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004957143,0.0002303456,0.0001837964,0.00009433245,0.00001126239,0.00004777131,0.00002140248,0.00008832268,0.9893824,0.0001039168,0.0002070987,0.009133681],"study_design_scores_gemma":[0.0003994036,0.005973392,0.003418485,0.00002028635,0.00005325661,0.0007503878,0.00005292821,0.0008272888,0.9781203,0.00009187194,0.01028264,0.000009852684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835079,0.007206471,0.004538961,0.0003561273,0.00008489078,0.00009547021,0.0004561402,0.0001980938,0.00355602],"genre_scores_gemma":[0.9798091,0.006610577,0.004884297,0.0002541523,0.00006049867,0.0001751669,0.001520195,0.00002873671,0.006657324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002207809,"threshold_uncertainty_score":0.00738585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02352499278651643,"score_gpt":0.2875170563331765,"score_spread":0.2639920635466601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}