{"id":"W613126169","doi":"10.1007/978-94-007-2774-8_8","title":"Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis","year":2011,"lang":"en","type":"book-chapter","venue":"","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Protein aggregation; Chemistry; Inclusion bodies; Protein folding; Oxidative stress; Spinal cord; Amyloid (mycology); Superoxide dismutase; Neurodegeneration; Motor neuron; Cell biology; Biochemistry; Biology; Pathology; Neuroscience; Medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349693,0.0008260944,0.000563944,0.001055826,0.0006182999,0.001508016,0.0005494873,0.001187629,0.02041377],"category_scores_gemma":[0.0002816716,0.0002429448,0.0002967833,0.0009659561,0.0005841063,0.002001082,0.000917671,0.001816624,0.01078673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127694,"about_ca_system_score_gemma":0.0006711755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266736,"about_ca_topic_score_gemma":0.003799278,"domain_scores_codex":[0.9998989,0.00001459571,0.000006144563,0.00001237764,0.00005964675,0.000008316449],"domain_scores_gemma":[0.9999154,0.00004108111,0.000005227816,0.000005972255,0.00002287152,0.000009443242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004030258,0.00007903681,0.00006511523,0.0007657454,0.000009847463,0.0002279249,0.0002793991,0.0007878403,0.003624062,0.0844515,0.5500416,0.3596276],"study_design_scores_gemma":[0.000002162749,0.00001199119,0.00008918412,0.0001712307,0.00000357818,0.0002755408,0.00002867652,0.0001196114,0.0003852065,0.01350348,0.9854046,0.000004828044],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.001341,0.4559281,0.009139873,0.008672951,0.01361158,0.00006715459,0.0003108177,0.0002868255,0.5106418],"genre_scores_gemma":[0.003613096,0.150983,0.003587462,0.003234922,0.002111391,0.00005897101,0.0001994771,0.0001097973,0.8361019],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02041377,"threshold_uncertainty_score":0.06829089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0749053919851859,"score_gpt":0.2671360050052484,"score_spread":0.1922306130200625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}