{"id":"W613303972","doi":"10.1182/blood.v124.21.409.409","title":"Efficacy and Safety of Lenalidomide (LEN) Versus Placebo (PBO) in RBC-Transfusion Dependent (TD) Patients (Pts) with IPSS Low/Intermediate (Int-1)-Risk Myelodysplastic Syndromes (MDS) without Del(5q) and Unresponsive or Refractory to Erythropoiesis-Stimulating Agents (ESAs): Results from a Randomized Phase 3 Study (CC-5013-MDS-005)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lenalidomide; Anemia; Internal medicine; Myelodysplastic syndromes; Placebo; Clinical endpoint; Randomization; Refractory (planetary science); Neutropenia; Gastroenterology; Randomized controlled trial; Surgery; Toxicity; Bone marrow; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001085533,0.0008664841,0.001686858,0.0003302446,0.0003086842,0.0008973684,0.0006425768,0.0009888734,0.002825176],"category_scores_gemma":[0.001247082,0.000403154,0.001227201,0.000298686,0.0009021836,0.000776902,0.0003412318,0.002566632,0.0004107039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008532925,"about_ca_system_score_gemma":0.00110782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000589586,"about_ca_topic_score_gemma":0.001320508,"domain_scores_codex":[0.9995351,0.000263468,0.0000375563,0.00007679971,0.00003409345,0.00005307457],"domain_scores_gemma":[0.9992201,0.0002049342,0.0002118385,0.00004145419,0.00002770442,0.0002938795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9500028,0.01037178,0.001334893,0.0003245641,0.0004997111,0.00003900116,0.0000564784,0.0006220673,0.005905481,0.00008501252,0.0004249094,0.0303333],"study_design_scores_gemma":[0.6888726,0.3008898,0.005142202,0.00004990749,0.0007355556,0.0001068408,0.00003868015,0.001037333,0.002178319,0.0002203129,0.0007056369,0.00002284626],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995288,0.002386376,0.0002049952,0.0002389644,0.0001108,0.0005409165,0.0003681326,0.00004220974,0.0008194564],"genre_scores_gemma":[0.9969568,0.0009128391,0.0004508135,0.0002912435,0.0001022857,0.0004765808,0.0003178542,0.000007285697,0.0004841715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825176,"threshold_uncertainty_score":0.009451151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859525542926867,"score_gpt":0.3049827407129871,"score_spread":0.2863874852837184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}