{"id":"W613697576","doi":"10.1021/acs.jmedchem.5b00216","title":"Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; CXC chemokine receptors; CCL21; Pentapeptide repeat; Chemokine receptor; CXCR3; Agonist; Receptor; Functional selectivity; CXCL14; C-C chemokine receptor type 6; CCL7; Pharmacology; Biochemistry; Chemokine; Peptide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885625,0.0004061898,0.0003670053,0.0001665849,0.0001276372,0.0002193766,0.0003459596,0.0002894232,0.001421047],"category_scores_gemma":[0.000138185,0.000179244,0.0002928059,0.0001393966,0.0001274445,0.0002660222,0.0002335225,0.0006777382,0.0006184563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362027,"about_ca_system_score_gemma":0.0002667115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000227877,"about_ca_topic_score_gemma":0.0004637674,"domain_scores_codex":[0.9998642,0.00002881072,0.00001070088,0.00002056596,0.00003399194,0.00004163766],"domain_scores_gemma":[0.9999411,0.00000687076,0.00001631717,0.00000484266,0.00001104482,0.00001972007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002320946,0.0001367738,0.0001797284,0.0001020029,0.00001756898,0.0001919945,0.00003419089,0.0008108955,0.9863974,0.0005724239,0.0004156822,0.01090931],"study_design_scores_gemma":[0.0002928288,0.004163272,0.00133903,0.00002177434,0.00007052828,0.001480873,0.00003519125,0.003434022,0.971155,0.0002245181,0.01774787,0.00003516203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719144,0.00553625,0.01429288,0.0004980257,0.0001239149,0.0004675341,0.000641751,0.0002262256,0.006298963],"genre_scores_gemma":[0.9626797,0.004978302,0.0261333,0.0007450864,0.00006461257,0.0002656272,0.001162241,0.00004764518,0.003923502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421047,"threshold_uncertainty_score":0.004753828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03305150573896805,"score_gpt":0.2765594177201543,"score_spread":0.2435079119811863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}