{"id":"W624928219","doi":"10.1038/mi.2015.46","title":"A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways","year":2015,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Genentech; McGill University; Burroughs Wellcome Fund","keywords":"Colitis; Inhibitor of apoptosis; Inflammasome; Colorectal cancer; Cancer research; RIPK1; Biology; Programmed cell death; Immunology; Caspase; Regeneration (biology); Mouse model of colorectal and intestinal cancer; Inflammation; Apoptosis; Cell biology; Cancer; Necroptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004084695,0.0001757597,0.0002803057,0.00005450591,0.00006829247,0.00001915419,0.0001444987,0.0002637359,0.000004268623],"category_scores_gemma":[0.001377968,0.0001510169,0.0000428162,0.0001118892,0.0005238439,0.00001119024,0.0001762171,0.0001674921,7.42308e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003048048,"about_ca_system_score_gemma":0.0001754222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004452781,"about_ca_topic_score_gemma":0.0006810867,"domain_scores_codex":[0.99877,0.0001855809,0.0003169155,0.0002672872,0.00009185066,0.0003683956],"domain_scores_gemma":[0.9993715,0.0001136714,0.000100658,0.0001311293,0.0002283054,0.00005472462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009203723,0.00010755,0.007752539,0.00002391193,0.00008466367,0.000002888453,0.0004009811,6.304496e-7,0.9880553,0.0002764916,0.0001437187,0.002230913],"study_design_scores_gemma":[0.005189438,0.002236728,0.02185605,0.00005912261,0.00004358116,0.00001391703,0.002405102,0.0002166333,0.9617224,0.0008917517,0.004983374,0.0003819529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987269,0.01141479,0.00001966577,0.0004195563,0.0001275653,0.0004966397,0.0001691075,0.00001032079,0.000073303],"genre_scores_gemma":[0.9990908,0.0002086499,0.00004384862,0.00004439114,0.00003905442,0.0002739366,0.0002451769,0.0000228143,0.00003134827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02633299,"threshold_uncertainty_score":0.6158291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064813181347629,"score_gpt":0.2356824249791618,"score_spread":0.2250342931656855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}