{"id":"W63174853","doi":"10.1007/978-3-7091-6301-6_17","title":"Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway","year":2000,"lang":"en","type":"review","venue":"","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas College; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Medical Research Council Canada; Alzheimer Society","keywords":"Neuroprotection; Protein kinase B; Growth factor; Insulin-like growth factor; Biology; Transcription factor; PI3K/AKT/mTOR pathway; Kinase; Neurodegeneration; Intracellular; Phosphorylation; Cell biology; Endocrinology; Internal medicine; Signal transduction; Neuroscience; Biochemistry; Medicine; Disease; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003684864,0.0009638903,0.00105062,0.00102177,0.0002450798,0.0008345593,0.000821272,0.0008554364,0.002060484],"category_scores_gemma":[0.0002481151,0.0001927201,0.0001962307,0.001514718,0.000621857,0.0009796331,0.0003646311,0.001385132,0.002113539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007311344,"about_ca_system_score_gemma":0.0007650757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067294,"about_ca_topic_score_gemma":0.001956842,"domain_scores_codex":[0.9999154,0.000007675647,0.00001063308,0.0000203604,0.00003632362,0.000009643838],"domain_scores_gemma":[0.999879,0.00003713504,0.00001843493,0.000005329389,0.00004039879,0.00001966191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002367309,0.00007371241,0.0002388669,0.004746829,0.00004764926,0.0004290123,0.00003299111,0.000401446,0.01052084,0.003528298,0.02832148,0.9514221],"study_design_scores_gemma":[0.00005641855,0.0001016013,0.0009965273,0.0007155586,0.00008606257,0.001810476,0.0000591606,0.0001464997,0.004793043,0.002475078,0.9887404,0.00001908616],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005577385,0.994368,0.000827406,0.0005825255,0.0005903313,0.000006840042,0.00003520117,0.00002471523,0.003007196],"genre_scores_gemma":[0.002267463,0.9940602,0.0007175559,0.0002863397,0.0003029999,0.00001068985,0.00006224681,0.00000358586,0.002288799],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002060484,"threshold_uncertainty_score":0.006892979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117078680458461,"score_gpt":0.2679345103238196,"score_spread":0.236763723519235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}