{"id":"W632797437","doi":"10.71781/27479","title":"The Role of Second Generation Antiretroviral Drugs in HIV-1 Subtype B and non-B Variants Harboring Natural Polymorphisms and Drug Resistance Mutations","year":2012,"lang":"en","type":"dissertation","venue":"Open MIND","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Styrelsen för Internationellt Utvecklingssamarbete; Université de Montréal; Harvard University; Pfizer","keywords":"Rilpivirine; Etravirine; Virology; Drug resistance; Reverse transcriptase; Biology; Protease; Resistance mutation; Mutation; Virus; Reverse-transcriptase inhibitor; Gene; Genetics; Viral load; Polymerase chain reaction; Antiretroviral therapy; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003308879,0.0001841317,0.0002993851,0.0002651486,0.0002177453,0.0008455922,0.0001883939,0.0003929278,0.001676528],"category_scores_gemma":[0.0006385475,0.00009980889,0.0003479172,0.0001725439,0.0001579472,0.0003042372,0.0002317512,0.0002930617,0.0001442376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003407053,"about_ca_system_score_gemma":0.0003416056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293578,"about_ca_topic_score_gemma":0.003363136,"domain_scores_codex":[0.9997621,0.00006733125,0.00001682455,0.00005555509,0.0000656343,0.00003249809],"domain_scores_gemma":[0.9996406,0.0001658166,0.00009862714,0.00001798784,0.00003466314,0.00004219958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00338384,0.0007004951,0.1907468,0.001712828,0.000615186,0.002490798,0.0008583603,0.003354463,0.2723328,0.005080372,0.003222812,0.5155013],"study_design_scores_gemma":[0.0005379527,0.01643057,0.5869925,0.001112606,0.00109601,0.02569074,0.002357825,0.01475921,0.2277143,0.007049291,0.1161248,0.0001343005],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331579,0.05594693,0.001386028,0.00119102,0.0001360491,0.00004289176,0.0003680945,0.00002699897,0.007744033],"genre_scores_gemma":[0.9776384,0.01632565,0.001749826,0.0002904206,0.00007165882,0.00002511808,0.0002729392,0.00001149316,0.003614446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676528,"threshold_uncertainty_score":0.005608559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009468075643566505,"score_gpt":0.2619745238141546,"score_spread":0.2525064481705881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}