{"id":"W636497264","doi":"10.1021/acs.bioconjchem.5b00160","title":"Determination of the Rat in Vivo Pharmacokinetic Profile of a Bone-Targeting Dual-Action Pro-Drug for Treatment of Osteoporosis","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Bone health and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Leading Edge Endowment Fund; Canada Foundation for Innovation","keywords":"Chemistry; In vivo; Bisphosphonate; Agonist; Pharmacokinetics; Drug; Pharmacology; Osteoporosis; Receptor; Hydrolysis; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203703,0.0001113587,0.0002974129,0.0000273338,0.000016555,0.000001501568,0.00002620766,0.00006200874,0.00002436474],"category_scores_gemma":[0.00006225029,0.00007765528,0.00008726445,0.0001121665,0.00005304975,0.00002925849,0.00001147816,0.00002728366,4.520686e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483284,"about_ca_system_score_gemma":0.00019226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001601712,"about_ca_topic_score_gemma":0.00000762649,"domain_scores_codex":[0.9991338,0.00001769332,0.0004185548,0.0001477194,0.0001442443,0.0001379376],"domain_scores_gemma":[0.9992428,0.00003039272,0.0003422612,0.0001570129,0.0001525884,0.00007491749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005951928,0.0006186893,0.0152734,0.001637242,0.00002046203,0.000002353685,0.0006386162,0.000001437104,0.9773108,5.256858e-7,0.0001804081,0.003720858],"study_design_scores_gemma":[0.005504485,0.0002590749,0.0008096457,0.0001660545,0.0001092548,0.000009236654,0.0003163984,0.0002882471,0.9918643,0.00001375236,0.0006082674,0.00005130693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977238,0.0003936004,0.000002658034,0.0001829309,0.00007946192,0.001201019,0.00005984408,0.000008532214,0.0003481452],"genre_scores_gemma":[0.9977701,0.00004620878,0.0007910117,0.00001056965,0.00003169341,0.0002465269,0.00004299239,0.00001255509,0.001048284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01455346,"threshold_uncertainty_score":0.316669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0454085919018531,"score_gpt":0.3304508863638498,"score_spread":0.2850422944619967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}