{"id":"W639440161","doi":"10.71781/31312","title":"The Development, Validation and Implementation of a Broad-Based ADME Genotyping Assay into Research and Clinical Trials","year":2011,"lang":"en","type":"dissertation","venue":"Papyrus : Institutional Repository (Université de Montréal)","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut de Cardiologie de Montréal; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Genome Canada; Crohn's and Colitis Foundation of America","keywords":"ADME; Genotyping; Computational biology; Data science; Medicine; Computer science; Medical physics; Pharmacology; Biology; Genetics; Genotype; Drug","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002859592,0.000150495,0.0002429399,0.00009413571,0.00309501,0.00003258708,0.000159659,0.0002674734,0.00000611188],"category_scores_gemma":[0.0009780426,0.0001166308,0.0001037727,0.00008831384,0.0004190505,0.000009308713,0.0001673821,0.0001976047,0.000001457162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883044,"about_ca_system_score_gemma":0.001493239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002487399,"about_ca_topic_score_gemma":0.008628105,"domain_scores_codex":[0.9978917,0.0007334775,0.0004615643,0.0003720791,0.000313281,0.0002278892],"domain_scores_gemma":[0.9985663,0.00038438,0.0002802277,0.0001653272,0.000437286,0.0001664461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01571935,0.0004934566,0.1889122,0.0007305089,0.002601472,0.00007396648,0.008734331,0.000007406469,0.3571027,0.008135507,0.001814414,0.4156747],"study_design_scores_gemma":[0.003133402,0.001222382,0.5397277,0.0002003357,0.0002759625,0.00001598082,0.03514995,0.00004447775,0.3742358,0.001737228,0.04368271,0.000573971],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759015,0.02131613,0.0001126373,0.00006312,0.0001182462,0.0004395271,0.00002184178,0.000007242224,0.00201978],"genre_scores_gemma":[0.9923013,0.004001217,0.000441288,0.00001398539,0.00008589325,0.00004309825,0.0006483715,0.000009524806,0.00245529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4151007,"threshold_uncertainty_score":0.9982028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0592753254245694,"score_gpt":0.3585375584286657,"score_spread":0.2992622330040963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}