{"id":"W639440161","doi":"10.71781/31312","title":"The Development, Validation and Implementation of a Broad-Based ADME Genotyping Assay into Research and Clinical Trials","year":2011,"lang":"en","type":"dissertation","venue":"Papyrus : Institutional Repository (Université de Montréal)","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut de Cardiologie de Montréal; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Genome Canada; Crohn's and Colitis Foundation of America","keywords":"ADME; Genotyping; Computational biology; Data science; Medicine; Computer science; Medical physics; Pharmacology; Biology; Genetics; Genotype; Drug","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.112082,0.001441202,0.002298113,0.00269891,0.0008071266,0.005485605,0.002738632,0.003638537,0.003898867],"category_scores_gemma":[0.07832903,0.0009108992,0.001471797,0.002272106,0.002529856,0.002468108,0.002759109,0.003203691,0.002355056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001512511,"about_ca_system_score_gemma":0.01016321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001359262,"about_ca_topic_score_gemma":0.001506141,"domain_scores_codex":[0.9223849,0.05484687,0.004652517,0.005709531,0.01066466,0.001741556],"domain_scores_gemma":[0.9379211,0.02306535,0.008454538,0.01024009,0.01671619,0.003602676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008945329,0.002316551,0.04987514,0.003147014,0.001390513,0.0004352291,0.001379734,0.009068204,0.1195027,0.01713442,0.009980021,0.7768251],"study_design_scores_gemma":[0.008115257,0.08006053,0.1318722,0.004176834,0.004572297,0.004857584,0.001385373,0.03236821,0.1952796,0.04191713,0.4945665,0.0008284281],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1206645,0.02959545,0.7674606,0.01623853,0.003116248,0.025707,0.006694497,0.003184834,0.02733827],"genre_scores_gemma":[0.3157141,0.01084448,0.6367471,0.008578703,0.0009459698,0.01470977,0.00520754,0.0003618564,0.006890434],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.112082,"threshold_uncertainty_score":0.5927536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0592753254245694,"score_gpt":0.3585375584286657,"score_spread":0.2992622330040963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}