{"id":"W644962373","doi":"10.1007/s00251-015-0852-3","title":"Transposon-mediated death of an ancestral A-23-like allele: evolution of TCR-positioning motifs in the HLA-A lineage","year":2015,"lang":"en","type":"article","venue":"Immunogenetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Biology; Allele; Genetics; Phylogenetics; Human leukocyte antigen; Sequence motif; Locus (genetics); Major histocompatibility complex; Structural motif; T-cell receptor; Phylogenetic tree; Gene; Evolutionary biology; T cell; Immune system; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749979,0.0002092449,0.0001718158,0.0003071852,0.0002398382,0.0004861648,0.0003401194,0.0005018545,0.001447715],"category_scores_gemma":[0.0002608934,0.0001363641,0.0002788529,0.0002015865,0.0002858941,0.000191235,0.0003708542,0.0008122277,0.0006600139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732264,"about_ca_system_score_gemma":0.0002100078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007826545,"about_ca_topic_score_gemma":0.001015151,"domain_scores_codex":[0.9998868,0.00002038873,0.000008656066,0.00002196723,0.00002474912,0.00003739191],"domain_scores_gemma":[0.999808,0.00004540558,0.00003733459,0.00003509154,0.00001924782,0.00005502498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005524038,0.00001112417,0.0009087224,0.000007173642,0.000006748648,0.000369778,0.00003357635,0.00008276067,0.9964174,0.0002870745,0.00001216006,0.001808315],"study_design_scores_gemma":[0.00006524858,0.0008162186,0.1084337,0.00003646101,0.0001232228,0.01062478,0.0005789452,0.005102016,0.8666635,0.001061841,0.006438454,0.00005552054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975406,0.00009760675,0.001403632,0.00002964864,0.000008569662,0.000006581074,0.00005677486,0.00002626213,0.000830369],"genre_scores_gemma":[0.9979371,0.00009830108,0.0006654667,0.00003180855,0.000004075609,0.000004288168,0.00008991361,0.00001918663,0.001149954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447715,"threshold_uncertainty_score":0.004843056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391150285985987,"score_gpt":0.2466768000171224,"score_spread":0.2227652971572625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}