{"id":"W644962373","doi":"10.1007/s00251-015-0852-3","title":"Transposon-mediated death of an ancestral A-23-like allele: evolution of TCR-positioning motifs in the HLA-A lineage","year":2015,"lang":"en","type":"article","venue":"Immunogenetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Biology; Allele; Genetics; Phylogenetics; Human leukocyte antigen; Sequence motif; Locus (genetics); Major histocompatibility complex; Structural motif; T-cell receptor; Phylogenetic tree; Gene; Evolutionary biology; T cell; Immune system; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717555,0.0002095614,0.0003737743,0.0001396346,0.00007992365,0.000008184085,0.0005499911,0.0003687444,0.00004279499],"category_scores_gemma":[0.00003620311,0.0001701827,0.0001001347,0.0002708988,0.0003948248,0.00008540528,0.00004247264,0.0003529743,0.00004704703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005697712,"about_ca_system_score_gemma":0.0001671406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006031257,"about_ca_topic_score_gemma":0.0001303407,"domain_scores_codex":[0.9981723,0.0004863818,0.0006288294,0.0002465649,0.0000822042,0.0003837079],"domain_scores_gemma":[0.9989619,0.0001250636,0.0002421771,0.0004808608,0.0001679547,0.00002202218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003214566,0.0005131259,0.007772058,0.00001961555,0.0001029064,0.000006310074,0.002357491,0.0005626792,0.987384,0.0002353177,0.00005323064,0.0006718773],"study_design_scores_gemma":[0.005013872,0.002758553,0.03949795,0.00007567197,0.0001549587,0.0001708166,0.003530414,0.0001862206,0.9434878,0.0003866204,0.004361258,0.0003759142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807757,0.01757857,0.0003774701,0.0000399598,0.0004608555,0.0003048203,0.00007110991,0.0000285222,0.0003630364],"genre_scores_gemma":[0.9985409,0.0003101852,0.0004296447,0.00003578344,0.00002558275,0.00002091157,0.0004737015,0.00001883096,0.0001444186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04389619,"threshold_uncertainty_score":0.693985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391150285985987,"score_gpt":0.2466768000171224,"score_spread":0.2227652971572625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}