{"id":"W647659435","doi":"10.1016/j.biopsych.2015.05.020","title":"Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist","year":2015,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec","funders":"National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism","keywords":"Naltrindole; Striatum; Morris water navigation task; Neuroscience; Motor coordination; Elevated plus maze; Rotarod performance test; Psychology; Opioid; Pharmacology; Opioid receptor; Medicine; Hippocampus; Endocrinology; Anxiety; Dopamine; Receptor; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002501782,0.001412769,0.0007371679,0.00109774,0.0003857368,0.0004787457,0.0006859619,0.001085229,0.008630197],"category_scores_gemma":[0.0002202835,0.0005641204,0.0006445933,0.0003726281,0.001416261,0.0005837932,0.0006468302,0.002623188,0.002217668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003859006,"about_ca_system_score_gemma":0.0003997023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108922,"about_ca_topic_score_gemma":0.001522908,"domain_scores_codex":[0.9995653,0.00004443003,0.00004880526,0.0001141472,0.00009671473,0.0001304962],"domain_scores_gemma":[0.9994736,0.00003380886,0.0002194889,0.00004537032,0.00002284332,0.000204837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009799931,0.0001495519,0.0003257713,0.00005094939,0.00001637858,0.0003716723,0.00003996963,0.0001214674,0.9956276,0.0003245223,0.0002440178,0.001748046],"study_design_scores_gemma":[0.0008059115,0.001731854,0.02474733,0.00007061709,0.0001696646,0.003746175,0.0004218012,0.002759419,0.9591779,0.0008581437,0.005448234,0.00006296173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904988,0.0004283974,0.003851981,0.0006874712,0.0001433475,0.00003463683,0.002392069,0.0004791742,0.001484083],"genre_scores_gemma":[0.9692937,0.0009313115,0.005018912,0.0004183488,0.00005440921,0.0001917454,0.002377996,0.0003631873,0.02135038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008630197,"threshold_uncertainty_score":0.02887082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197466658737893,"score_gpt":0.2404973172166217,"score_spread":0.2285226506292428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}