{"id":"W647659435","doi":"10.1016/j.biopsych.2015.05.020","title":"Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist","year":2015,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec","funders":"National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism","keywords":"Naltrindole; Striatum; Morris water navigation task; Neuroscience; Motor coordination; Elevated plus maze; Rotarod performance test; Psychology; Opioid; Pharmacology; Opioid receptor; Medicine; Hippocampus; Endocrinology; Anxiety; Dopamine; Receptor; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190557,0.0002569344,0.0002327789,0.00002076327,0.0001624488,0.00006102473,0.0001914348,0.0004330837,0.00006100942],"category_scores_gemma":[0.000122971,0.0002043768,0.0001142096,0.00005760594,0.0001042214,0.000005444689,0.0001490162,0.0002315365,0.000008880803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001646648,"about_ca_system_score_gemma":0.0000831069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009246537,"about_ca_topic_score_gemma":0.00002983344,"domain_scores_codex":[0.9985342,0.0001269244,0.0002612968,0.0006034796,0.0001103245,0.0003637481],"domain_scores_gemma":[0.9993733,0.00001136323,0.0001331254,0.0001766879,0.00007278421,0.0002327689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002732509,0.00008287095,0.03703629,0.00001613396,0.00002956911,7.057741e-7,0.00001564978,0.000003489364,0.9567945,0.00005739355,0.003272204,0.002417914],"study_design_scores_gemma":[0.0101088,0.0108814,0.009377681,0.0001413783,0.0001318067,0.0001572385,0.002569393,0.004132493,0.3331976,0.00174127,0.6239998,0.003561129],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905248,0.003286879,0.004451192,0.0001607002,0.0008498576,0.0002376818,0.00006620587,0.00004664554,0.0003760639],"genre_scores_gemma":[0.9933271,0.0006224088,0.004078507,0.0005120814,0.0006640215,0.00001625294,0.0003757478,0.00002572639,0.0003781767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.623597,"threshold_uncertainty_score":0.8334243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197466658737893,"score_gpt":0.2404973172166217,"score_spread":0.2285226506292428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}