{"id":"W654691995","doi":"10.1016/j.vaccine.2015.05.097","title":"Influence of HEK293 metabolism on the production of viral vectors and vaccine","year":2015,"lang":"en","type":"review","venue":"Vaccine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; National Research Council Canada","funders":"","keywords":"HEK 293 cells; Viral vector; Biology; Cellular metabolism; Cell culture; Productivity; Metabolism; Computational biology; Recombinant DNA; Biotechnology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293575,0.000253938,0.0006973862,0.00007693735,0.00004251768,0.00000668159,0.0001881471,0.0001788182,0.00001238704],"category_scores_gemma":[0.0003303448,0.0001469131,0.0001835409,0.0001585486,0.00001734135,0.000003776174,0.00014132,0.0001276901,0.000003020495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007792813,"about_ca_system_score_gemma":0.0001019445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002454665,"about_ca_topic_score_gemma":0.000003932712,"domain_scores_codex":[0.9988448,0.0001381695,0.0004139355,0.0003342718,0.0001386051,0.0001302308],"domain_scores_gemma":[0.9987898,0.00002383576,0.0004180168,0.0005440315,0.0001722154,0.00005206789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009344571,0.001049221,0.0006288774,0.02286349,0.002115924,0.000005814523,0.0001706505,0.00104272,0.07123837,0.00145896,0.1261516,0.7723399],"study_design_scores_gemma":[0.0002598687,0.0005042146,0.0005155443,0.001797199,0.0004161202,0.00001810671,0.000005720401,7.665351e-7,0.01075066,0.00008870247,0.9854182,0.0002249189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2439819,0.7553527,8.362509e-7,0.00002770266,0.0001950952,0.0003609202,0.00003454745,0.000005146992,0.00004110429],"genre_scores_gemma":[0.07250728,0.9267986,0.000009957409,0.00003520363,0.0003508132,0.00004928487,0.00004767127,0.0000274641,0.000173749],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8592666,"threshold_uncertainty_score":0.5990944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779098591626629,"score_gpt":0.2991091816820237,"score_spread":0.2813181957657573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}