{"id":"W655017083","doi":"10.1182/blood.v124.21.3197.3197","title":"Safety and Efficacy of Ruxolitinib in an Open-Label, Multicenter, Single-Arm, Expanded-Access Study in Patients with Myelofibrosis (MF): An 1144-Patient Update","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Internal medicine; Clinical endpoint; Tolerability; Discontinuation; Clinical trial; Phases of clinical research; Placebo; Surgery; Adverse effect; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004856203,0.0005352234,0.002111509,0.0005791846,0.0002645517,0.001442669,0.0007676654,0.001114066,0.002508259],"category_scores_gemma":[0.003079161,0.000285923,0.001150597,0.0009192935,0.000309197,0.0009498757,0.0003481674,0.001209712,0.0007628443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004543544,"about_ca_system_score_gemma":0.0006131367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000474597,"about_ca_topic_score_gemma":0.001035059,"domain_scores_codex":[0.9988769,0.0005120547,0.0001820703,0.00009737772,0.0002588261,0.00007273332],"domain_scores_gemma":[0.9963166,0.001264793,0.001097148,0.0001646654,0.0006886447,0.0004681571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1181015,0.004571914,0.1882972,0.007019443,0.00975656,0.001148353,0.000474909,0.0008859688,0.02069875,0.0006050922,0.04354969,0.6048906],"study_design_scores_gemma":[0.1333683,0.07143196,0.5902289,0.002589075,0.01837144,0.003919163,0.0003324614,0.002382135,0.006483839,0.0007787417,0.1698252,0.0002887119],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7820235,0.1792114,0.003348948,0.005472393,0.0008511039,0.002044526,0.0126597,0.0004714597,0.01391681],"genre_scores_gemma":[0.8991827,0.05493939,0.006883787,0.008120483,0.002683466,0.00172335,0.02250559,0.0001084796,0.003852757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004856203,"threshold_uncertainty_score":0.02568233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038952331248791,"score_gpt":0.3090227859298585,"score_spread":0.2786332626173706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}