{"id":"W658842411","doi":"10.1371/journal.pone.0128310","title":"Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Styrelsen för Internationellt Utvecklingssamarbete; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Integrase; Integrase inhibitor; Allosteric regulation; Binding site; DNA; Reverse transcriptase; Chemistry; Biology; Biochemistry; Virology; Enzyme; Human immunodeficiency virus (HIV); RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181792,0.0004675929,0.0006360536,0.0002685182,0.0001957572,0.0002710869,0.0005808522,0.0002679665,0.001009752],"category_scores_gemma":[0.0003419924,0.0001866667,0.0003319413,0.0003763841,0.0001687995,0.0001759169,0.0001553677,0.0004428489,0.000248428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005629701,"about_ca_system_score_gemma":0.0004516949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002410709,"about_ca_topic_score_gemma":0.002486116,"domain_scores_codex":[0.9998472,0.00002775569,0.00001050491,0.00002407284,0.0000698326,0.00002069477],"domain_scores_gemma":[0.9999092,0.000021882,0.00001887688,0.000008373509,0.00001960222,0.00002214673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00022941,0.0001649512,0.0007580518,0.0001388061,0.00002259064,0.0001289741,0.0000346132,0.005265208,0.9890581,0.0001478461,0.00007827241,0.003973069],"study_design_scores_gemma":[0.0001176525,0.00140309,0.00471436,0.00001344019,0.00008878906,0.0005215299,0.00003672636,0.01170062,0.9784681,0.00007544793,0.002845932,0.0000143523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928461,0.002127516,0.002910399,0.00009712257,0.000005751181,0.00008046463,0.0007627511,0.00004611547,0.001123719],"genre_scores_gemma":[0.9864677,0.002575952,0.007113592,0.0000416265,0.000005102158,0.00004075124,0.00221486,0.00001888846,0.001521625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002410709,"threshold_uncertainty_score":0.004793346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09411689921232547,"score_gpt":0.2701129649275275,"score_spread":0.175996065715202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}