{"id":"W67597426","doi":"10.1007/978-1-60761-588-0_14","title":"Nonviral siRNA Delivery for Gene Silencing in Neurodegenerative Diseases","year":2010,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; Disease; Viral vector; Gene delivery; Genetic enhancement; Amyotrophic lateral sclerosis; Blood–brain barrier; Medicine; RNA interference; Drug discovery; Neuroscience; Biology; Bioinformatics; Computational biology; Gene; RNA; Central nervous system; Pathology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001911,0.0004288747,0.0004374762,0.0004211355,0.0002965924,0.0005272723,0.0005352843,0.0005575194,0.001778827],"category_scores_gemma":[0.0002490883,0.0001835511,0.0003126248,0.0002321207,0.0003908827,0.0004135451,0.0004445628,0.0005663494,0.00119239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005681547,"about_ca_system_score_gemma":0.0005845911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007074947,"about_ca_topic_score_gemma":0.001022269,"domain_scores_codex":[0.9995691,0.00008586283,0.0000364435,0.0000878029,0.000185289,0.0000354634],"domain_scores_gemma":[0.9999045,0.00002406322,0.00002362437,0.00001037673,0.00002368471,0.00001368418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006245888,0.00004139278,0.00005609124,0.0003629712,0.00001231562,0.0001539535,0.00006014297,0.0001838533,0.9691422,0.002217056,0.0006323735,0.02707509],"study_design_scores_gemma":[0.00003993759,0.0005062535,0.0007137174,0.00005619081,0.00005185514,0.0008308699,0.00002990163,0.003082836,0.9470323,0.0009564746,0.04667972,0.00001990456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3447699,0.1597688,0.4546459,0.002356435,0.001439038,0.001152633,0.0009747584,0.002520886,0.0323716],"genre_scores_gemma":[0.7929044,0.06205516,0.1058012,0.001039007,0.0002567408,0.0008550399,0.001170377,0.0003241477,0.03559396],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001778827,"threshold_uncertainty_score":0.005950809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550181890589408,"score_gpt":0.3634303582243028,"score_spread":0.3479285393184087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}