{"id":"W67597426","doi":"10.1007/978-1-60761-588-0_14","title":"Nonviral siRNA Delivery for Gene Silencing in Neurodegenerative Diseases","year":2010,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; Disease; Viral vector; Gene delivery; Genetic enhancement; Amyotrophic lateral sclerosis; Blood–brain barrier; Medicine; RNA interference; Drug discovery; Neuroscience; Biology; Bioinformatics; Computational biology; Gene; RNA; Central nervous system; Pathology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000512877,0.0002367473,0.000293959,0.000168673,0.00004295164,0.00001600432,0.000338915,0.0003242105,0.00001518801],"category_scores_gemma":[0.0005141456,0.0002324755,0.0001551369,0.0001428868,0.0001380036,0.000005252504,0.0001696838,0.0002491466,0.000003097584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001444787,"about_ca_system_score_gemma":0.0001133195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006796377,"about_ca_topic_score_gemma":0.0002241229,"domain_scores_codex":[0.9980474,0.0004630109,0.0003539938,0.0006581732,0.00004929199,0.0004280897],"domain_scores_gemma":[0.9992557,0.00008654706,0.00008395325,0.0004183719,0.00008082262,0.00007462053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001247888,0.00007075377,0.00666899,0.000007951033,0.00002120982,0.00001552971,0.00003845423,0.0002032501,0.9822738,0.0002970046,0.00004381336,0.01023445],"study_design_scores_gemma":[0.0007018794,0.0004305891,0.002247891,0.000006634316,0.00001384776,0.00001173123,0.00003812429,0.0006627698,0.9926716,0.001377024,0.001556075,0.0002818089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7170001,0.0006519998,0.2814262,0.00006317816,0.0004637517,0.0002446443,0.00003883099,0.000007286993,0.0001040866],"genre_scores_gemma":[0.6757464,0.0001193989,0.3226926,0.0007996741,0.0001974008,0.0001664138,0.0001727736,0.00003191511,0.0000734092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04126646,"threshold_uncertainty_score":0.9480075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550181890589408,"score_gpt":0.3634303582243028,"score_spread":0.3479285393184087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}