{"id":"W68749225","doi":"10.1089/cell.2011.0079","title":"Treatment of Nuclear-Donor Cells or Cloned Zygotes with Chromatin-Modifying Agents Increases Histone Acetylation But Does Not Improve Full-Term Development of Cloned Cattle","year":2012,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Trichostatin A; Somatic cell nuclear transfer; Biology; Chromatin; Reprogramming; Histone deacetylase; Histone; DNA methylation; Acetylation; Molecular biology; Epigenetics; Somatic cell; Cell biology; Embryo; Genetics; Embryogenesis; DNA; Cell; Blastocyst; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684135,0.0003364711,0.0003472402,0.0002026507,0.0001503667,0.0003998703,0.0003748603,0.0003490166,0.002824748],"category_scores_gemma":[0.0002734827,0.0001448167,0.0003366499,0.0001283061,0.0001694465,0.0002032412,0.0002255587,0.0005696844,0.0005930151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154775,"about_ca_system_score_gemma":0.0003011114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532316,"about_ca_topic_score_gemma":0.002160077,"domain_scores_codex":[0.999759,0.00004600094,0.00002793232,0.00006101247,0.00006300015,0.00004308796],"domain_scores_gemma":[0.999689,0.0001013149,0.00006980616,0.0000359308,0.00003763254,0.00006633071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008299104,0.00001574251,0.0002478707,0.00005060953,0.000006273062,0.00004999645,0.0000223057,0.00002744569,0.9977027,0.00002606065,0.00002312548,0.001744885],"study_design_scores_gemma":[0.00001130761,0.0007995444,0.007334842,0.00001707923,0.00004561072,0.0003612838,0.00005786337,0.0002365194,0.9868082,0.00002529706,0.004296313,0.000006176909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827624,0.007866279,0.004673325,0.0001499823,0.0001002425,0.00003922302,0.0007703416,0.000101952,0.003536209],"genre_scores_gemma":[0.9837794,0.003228652,0.003394236,0.00009624042,0.00002017397,0.0000405026,0.001365482,0.00006103614,0.008014316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002824748,"threshold_uncertainty_score":0.00944972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641925435262062,"score_gpt":0.2851648932354235,"score_spread":0.2587456388828029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}