{"id":"W68749225","doi":"10.1089/cell.2011.0079","title":"Treatment of Nuclear-Donor Cells or Cloned Zygotes with Chromatin-Modifying Agents Increases Histone Acetylation But Does Not Improve Full-Term Development of Cloned Cattle","year":2012,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Trichostatin A; Somatic cell nuclear transfer; Biology; Chromatin; Reprogramming; Histone deacetylase; Histone; DNA methylation; Acetylation; Molecular biology; Epigenetics; Somatic cell; Cell biology; Embryo; Genetics; Embryogenesis; DNA; Cell; Blastocyst; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003033855,0.0003050021,0.0004053414,0.00009894658,0.0001730571,0.0000273135,0.0002151049,0.0001729045,0.00004697208],"category_scores_gemma":[0.0000492372,0.000211872,0.0001323325,0.0001261357,0.0001762071,0.00001991024,0.0001713573,0.00006857983,0.00001190457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343259,"about_ca_system_score_gemma":0.0001536429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001930732,"about_ca_topic_score_gemma":0.00003572438,"domain_scores_codex":[0.9978945,0.0001006207,0.0005652949,0.0005121409,0.0003743795,0.0005530693],"domain_scores_gemma":[0.9985577,0.00003446203,0.0004270685,0.0006365463,0.0001487087,0.0001955259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008091141,0.0008679026,0.003873018,0.0003273764,0.0002329998,0.000009968124,0.0008361686,0.00001202681,0.971112,0.000002154819,0.000004202154,0.02191312],"study_design_scores_gemma":[0.00138842,0.0008892074,0.001054355,0.00005895297,0.00008141577,0.0000137769,0.0004241515,0.0001133767,0.9936796,4.215274e-7,0.00201922,0.0002770666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971563,0.0007076825,0.001106436,0.00001526275,0.0001064664,0.0007951637,0.00002365069,0.00002724021,0.0000617877],"genre_scores_gemma":[0.9803709,0.0001143765,0.01794541,0.000005332805,0.0001212198,0.0000811206,0.0002207697,0.00006341111,0.0010774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02256768,"threshold_uncertainty_score":0.8639888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641925435262062,"score_gpt":0.2851648932354235,"score_spread":0.2587456388828029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}