{"id":"W6884323378","doi":"10.1021/acs.jcim.0c00890.s001","title":"Structural Assessment of Agonist Efficacy in the μ‑Opioid\\nReceptor: Morphine and Fentanyl Elicit Different Activation Patterns","year":2021,"lang":"en","type":"article","venue":"Figshare","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fentanyl; Morphine; Agonist; Opioid; μ-opioid receptor; G protein-coupled receptor; Opioid receptor; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498413,0.0003596687,0.0003529916,0.0001764266,0.000447088,0.0003326465,0.0005913684,0.0004696545,0.004331893],"category_scores_gemma":[0.0003892506,0.0002235626,0.0003394579,0.0002034549,0.0003000952,0.0004173647,0.0003670748,0.0007628145,0.0003046859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006401208,"about_ca_system_score_gemma":0.000721437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005968086,"about_ca_topic_score_gemma":0.006562809,"domain_scores_codex":[0.9999115,0.000008211216,0.000004258538,0.00001488125,0.00002842863,0.00003274741],"domain_scores_gemma":[0.9998997,0.00003198152,0.00001314069,0.000007200835,0.00002431105,0.00002361797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002375669,0.001220464,0.02105341,0.00130594,0.0003950981,0.001252882,0.0008148385,0.4043941,0.527372,0.01379173,0.00630794,0.0197159],"study_design_scores_gemma":[0.0003555516,0.001624521,0.02073614,0.00007927657,0.0001502101,0.0003119046,0.0006403177,0.8847706,0.08471353,0.001752862,0.004782894,0.00008218741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939737,0.0004306693,0.001454632,0.0001787346,0.00001823128,0.00001682356,0.0004658302,0.0000617995,0.003399535],"genre_scores_gemma":[0.9958647,0.0005273733,0.001574133,0.00007132588,0.000004615105,0.00004469973,0.001172237,0.0000352086,0.0007056712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005968086,"threshold_uncertainty_score":0.01449162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0233906372543978,"score_gpt":0.2831349892763028,"score_spread":0.259744352021905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}