{"id":"W6884722332","doi":"10.1192/j.eurpsy.2023.1175","title":"A proof-of concept randomized controlled trial to show that the antidepressant effect of psilocybin does not require a psychedelic experience: study protocol","year":2023,"lang":"en","type":"article","venue":"PubMed Central","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Psilocybin; Antidepressant; Hallucinogen; Tolerability; Randomized controlled trial; Fluoxetine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01272378,0.004641361,0.00902627,0.001038076,0.00156708,0.002467652,0.002145159,0.007578145,0.05679184],"category_scores_gemma":[0.01368233,0.001603653,0.004787777,0.001203937,0.002433297,0.002882381,0.001159608,0.00541182,0.008153638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001906069,"about_ca_system_score_gemma":0.00614017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803478,"about_ca_topic_score_gemma":0.001852651,"domain_scores_codex":[0.9929766,0.003624852,0.0007304895,0.001176653,0.000636761,0.0008546892],"domain_scores_gemma":[0.9928235,0.002354571,0.002016272,0.0008201618,0.0009812693,0.001004272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9608155,0.006765408,0.0002795517,0.007983995,0.002618355,0.00009987202,0.0000736911,0.0004803884,0.00128958,0.001215901,0.004533042,0.01384478],"study_design_scores_gemma":[0.9695444,0.02216679,0.0004938433,0.0005399588,0.0009667807,0.00002472626,0.00001744643,0.0004131825,0.0002397568,0.001090408,0.004472332,0.00003030999],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04658507,0.006168921,0.01039839,0.002211081,0.005755054,0.9145535,0.005462306,0.0006172076,0.008248347],"genre_scores_gemma":[0.06379,0.001363018,0.009531446,0.002030548,0.0005553946,0.9183905,0.0008095199,0.00003633958,0.003493269],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05679184,"threshold_uncertainty_score":0.1899877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04658879839025823,"score_gpt":0.3745405348961821,"score_spread":0.3279517365059238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}