{"id":"W6886033456","doi":"10.14288/1.0449339","title":"Early-Life Adversity and Epigenetic Aging : Findings from a 17-Year Longitudinal Study","year":2025,"lang":"en","type":"article","venue":"Open Collections","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epigenetics; Stressor; Longitudinal study; DNA methylation; Longitudinal data; Sensitization; Prenatal stress","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001256935,0.0002430541,0.0002886945,0.000734863,0.00111429,0.0006581308,0.0005665697,0.0003781882,0.001238355],"category_scores_gemma":[0.0015448,0.0002777025,0.0003371845,0.00119395,0.0002892171,0.0003540147,0.0007458112,0.0007387872,0.0002063894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001644245,"about_ca_system_score_gemma":0.001900367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.461464,"about_ca_topic_score_gemma":0.6207414,"domain_scores_codex":[0.9996938,0.00007223605,0.00002094085,0.0000643948,0.00005392222,0.00009476559],"domain_scores_gemma":[0.9988124,0.0001019725,0.0003173798,0.000100431,0.0003164498,0.0003512404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004505205,0.00003865767,0.9978521,0.000006553394,0.00004628218,0.00004684998,0.0004447457,0.00001242615,0.00008639502,0.00001794884,0.0002014909,0.001201557],"study_design_scores_gemma":[0.000002358126,0.00001588629,0.9993072,0.000007827319,0.00001906409,0.00002687309,0.0003306126,0.00002558376,0.00001578361,0.000006956565,0.0002403364,0.000001693409],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977557,0.0003279683,0.00009033195,0.0001307075,0.000006488053,0.00001641802,0.001338919,0.000002768162,0.0003306437],"genre_scores_gemma":[0.997083,0.0005031141,0.0001952774,0.0001017252,0.000008005534,0.00003662198,0.001272183,0.000004371248,0.0007958145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.461464,"threshold_uncertainty_score":0.9175559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848618125548673,"score_gpt":0.288458839469686,"score_spread":0.2699726582141992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}