{"id":"W6887883005","doi":"10.17863/cam.113658","title":"Childhood, adolescent, and young adulthood cancer risk in BRCA1 or BRCA2 pathogenic variant carriers.","year":2024,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; European Regional Development Fund; Instituto de Salud Carlos III; National Cancer Institute; National Medical Research Council; Medical Research Council; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Royal Marsden NHS Foundation Trust; Department of Health and Social Care; National Institutes of Health; Terry Fox Foundation; Lee Foundation; Gray Foundation; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Deutsche Krebshilfe; Fundación Mutua Madrileña; National Health and Medical Research Council; Freistaat Sachsen; Cancer Research UK","keywords":"Young adult; Breast cancer; Cancer; Germline; Ovarian cancer; Genetic testing; Family history; Relative risk","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006784989,0.000189428,0.0001746158,0.0007154847,0.0002141277,0.0003047568,0.0001593457,0.0003257826,0.001413745],"category_scores_gemma":[0.002609989,0.0001582668,0.0003404459,0.000637904,0.0001974802,0.0002658683,0.0002599444,0.000341298,0.0001155396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993678,"about_ca_system_score_gemma":0.0002015607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006083891,"about_ca_topic_score_gemma":0.007373122,"domain_scores_codex":[0.9996812,0.00008957271,0.00003139902,0.00009766743,0.00005112234,0.0000490577],"domain_scores_gemma":[0.9979772,0.0005706208,0.001067809,0.00009636043,0.00008753234,0.0002004736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005725395,0.000004354478,0.9985183,0.000008543853,0.00003311937,0.00006539156,0.00003031116,0.00002262712,0.00008676003,0.00001281195,0.00003906674,0.001121489],"study_design_scores_gemma":[0.000002938434,0.00006363009,0.9987115,0.00001353696,0.0000476059,0.0007575738,0.00006804037,0.00007127217,0.00006431736,0.00002532037,0.0001725785,0.000001532066],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971787,0.001886878,0.00007564179,0.00004373834,0.000005607441,0.000004155659,0.0004017886,0.000003597953,0.0004000207],"genre_scores_gemma":[0.9988709,0.0006837503,0.00009769982,0.00001572772,0.000006624455,0.00000351399,0.0002315981,0.000001559051,0.00008861336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006083891,"threshold_uncertainty_score":0.012097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006263327026015915,"score_gpt":0.2220592879956517,"score_spread":0.2157959609696358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}