{"id":"W6887884821","doi":"10.17863/cam.64254","title":"Pan-cancer analysis of whole genomes","year":2018,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft; Centro Singular de Investigación de Galicia; Universidade de Santiago de Compostela; Universidade de Vigo; Barcelona Supercomputing Center; University of Texas MD Anderson Cancer Center; Université de Lausanne; Hospital for Sick Children; University of Tokyo; Université de Genève; Eberhard Karls Universität Tübingen; Barcelona Institute of Science and Technology; University of Toronto; Universitat Pompeu Fabra; Norges Teknisk-Naturvitenskapelige Universitet; Washington University in St. Louis; Massachusetts Eye and Ear; Alvin J. Siteman Cancer Center; Institute of Medical Science, University of Tokyo; School of Medicine, Stanford University; Deutsches Krebsforschungszentrum","keywords":"Genome; Germline; Somatic cell; Germline mutation; Gene; Telomere; Cancer genome sequencing; Genomics; Point mutation; Structural variation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001260445,0.0008493836,0.0007982928,0.003055781,0.0006552378,0.001205155,0.0007439574,0.0004449041,0.006443546],"category_scores_gemma":[0.001987767,0.0002810886,0.001060162,0.005292317,0.000239766,0.0005054657,0.001757758,0.0009906971,0.002029043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007610661,"about_ca_system_score_gemma":0.001042222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004707794,"about_ca_topic_score_gemma":0.005592234,"domain_scores_codex":[0.9989679,0.0001001055,0.00005373697,0.0005039869,0.0002620758,0.000112157],"domain_scores_gemma":[0.9990263,0.0002139148,0.0001576111,0.0002418938,0.0002564533,0.0001038718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002327268,0.000282442,0.1497101,0.003789344,0.00429639,0.001178982,0.0008202063,0.01371899,0.5761583,0.007707816,0.05837967,0.1816306],"study_design_scores_gemma":[0.0002057215,0.0003896094,0.539901,0.0002829062,0.001556335,0.002667683,0.0004521557,0.02972338,0.1547599,0.009591646,0.2603309,0.0001387281],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.3792115,0.008562642,0.1202044,0.0009870831,0.0003190394,0.0003870991,0.4621041,0.0142748,0.01394923],"genre_scores_gemma":[0.3477936,0.002111032,0.1098935,0.0005971944,0.0001031639,0.0004162375,0.5342081,0.001816077,0.003061072],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006443546,"threshold_uncertainty_score":0.02155584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007951162059477027,"score_gpt":0.2220113181459874,"score_spread":0.2140601560865104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}