{"id":"W6887912513","doi":"10.17863/cam.99119","title":"Natural selection has driven the recurrent loss of an immunity gene that protects Drosophila against a major natural parasite.","year":2023,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Cambridge Trust; Erasmus+; Natural Environment Research Council; Gates Cambridge Trust; Sight Research UK","keywords":"Gene; Allele; Natural selection; Immune system; Immunity; Innate immune system; Drosophila melanogaster; Function (biology); Pleiotropy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004572509,0.0002306113,0.0003895424,0.0002938579,0.0007765361,0.00001541987,0.0006870693,0.000241697,0.00003727929],"category_scores_gemma":[0.00005181408,0.0002153713,0.0002288151,0.0006769176,0.0006358082,0.0002807911,0.0002785678,0.0006456595,0.0001698175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029679,"about_ca_system_score_gemma":0.0001723385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001023469,"about_ca_topic_score_gemma":0.0002827672,"domain_scores_codex":[0.9982252,0.0007225528,0.0001917704,0.0003121561,0.0001234991,0.0004248274],"domain_scores_gemma":[0.9989041,0.00009923347,0.0003119364,0.0004723452,0.000182704,0.00002969545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001146337,0.0001131984,0.0003429145,0.00004131463,0.0003312372,0.00002925508,0.001526688,0.00001383729,0.9913896,0.0006087103,0.001214335,0.003242561],"study_design_scores_gemma":[0.003252367,0.0006394183,0.0905735,0.0001148308,0.0001598864,0.0001827012,0.0035766,0.002031844,0.89573,0.00009963784,0.003177422,0.0004617418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99669,0.0006102982,0.00008045564,0.0006950623,0.001045325,0.0005884163,0.00006669642,0.0001385995,0.00008508918],"genre_scores_gemma":[0.9957206,0.0001009711,0.0001247928,0.00004909153,0.00001812713,0.000002340831,0.0003085635,0.00002009581,0.003655446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09565957,"threshold_uncertainty_score":0.8782586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662478949277189,"score_gpt":0.2156731214231486,"score_spread":0.1990483319303767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}