{"id":"W6887916162","doi":"10.17863/cam.96078","title":"Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.","year":2023,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"NIHR Leicester Biomedical Research Centre; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; MRC-PHE Centre for Environment and Health; Universiteit Gent; British Lung Foundation; University of Oxford; University of Texas Health Science Center at Houston; Imperial College London; National Institutes of Health; University of Leicester; Peking University; National Institute for Health and Care Research; Institute of Genetics; National Health and Medical Research Council; Peking University Health Science Center; Medical Research Council; Brigham and Women's Hospital; British Heart Foundation; UK Research and Innovation; Universität Basel; NIHR Nottingham Biomedical Research Centre; School of Public Health, Imperial College London; University of Bristol; COPD Foundation","keywords":"COPD; Genome-wide association study; Genetic association; Lung function; Gene; Disease; Pulmonary disease; Association (psychology); Function (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002576942,0.00009336346,0.0001778827,0.00008549906,0.000165164,0.000003974228,0.00006317567,0.0001338165,0.000001687616],"category_scores_gemma":[0.0002329948,0.0001132758,0.00007219171,0.0001469692,0.00009288909,0.00001511488,0.0001220809,0.00006410862,9.980495e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007833383,"about_ca_system_score_gemma":0.00008488786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004781119,"about_ca_topic_score_gemma":0.00009569815,"domain_scores_codex":[0.9992336,0.0001129366,0.0001383501,0.0002632361,0.00008654187,0.0001653411],"domain_scores_gemma":[0.9992488,0.00006879363,0.0003577744,0.0001413921,0.0001149475,0.00006828532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005454868,0.00001353738,0.7609903,0.00004621499,0.000125969,0.000001296868,0.00005908366,0.0008725303,0.2365645,0.000007906302,0.00009133364,0.001172777],"study_design_scores_gemma":[0.0003816592,0.00007147525,0.9890578,0.000008190432,0.0001797265,4.614916e-7,0.0008717962,0.008199756,0.0009254473,0.00004009556,0.0001625018,0.0001010592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940149,0.002299476,0.00322543,0.00007595099,0.00005851071,0.000115774,0.0001620268,0.00001138152,0.00003650289],"genre_scores_gemma":[0.9965422,0.002355945,0.000560506,0.00001409034,0.00004469743,8.777591e-7,0.0001541537,0.000006660842,0.0003208642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2356391,"threshold_uncertainty_score":0.4619254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171762429043856,"score_gpt":0.2384154847586767,"score_spread":0.2212392418542911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}