{"id":"W6887916162","doi":"10.17863/cam.96078","title":"Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.","year":2023,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"NIHR Leicester Biomedical Research Centre; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; MRC-PHE Centre for Environment and Health; Universiteit Gent; British Lung Foundation; University of Oxford; University of Texas Health Science Center at Houston; Imperial College London; National Institutes of Health; University of Leicester; Peking University; National Institute for Health and Care Research; Institute of Genetics; National Health and Medical Research Council; Peking University Health Science Center; Medical Research Council; Brigham and Women's Hospital; British Heart Foundation; UK Research and Innovation; Universität Basel; NIHR Nottingham Biomedical Research Centre; School of Public Health, Imperial College London; University of Bristol; COPD Foundation","keywords":"COPD; Genome-wide association study; Genetic association; Lung function; Gene; Disease; Pulmonary disease; Association (psychology); Function (biology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004511953,0.0007404223,0.001254561,0.002464343,0.0008599791,0.001987489,0.0006860449,0.001056824,0.007168413],"category_scores_gemma":[0.01274611,0.0005624233,0.001400507,0.003186667,0.0003215196,0.0006961189,0.002205668,0.001705072,0.0008096143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002264691,"about_ca_system_score_gemma":0.0004183352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005936936,"about_ca_topic_score_gemma":0.01691162,"domain_scores_codex":[0.9967418,0.001944545,0.0001744944,0.0006764715,0.0002489394,0.0002137457],"domain_scores_gemma":[0.9917912,0.004969103,0.001078501,0.001440324,0.0003326657,0.0003881419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002320051,0.0001659502,0.8407671,0.0004417449,0.009077109,0.0008116263,0.0003954293,0.002669155,0.02959605,0.002535324,0.005722121,0.1054984],"study_design_scores_gemma":[0.0002331281,0.0002233767,0.960934,0.0001458229,0.003604613,0.001388368,0.0002042771,0.00940884,0.004153898,0.007385798,0.01224884,0.00006911031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8785757,0.01893999,0.07798321,0.004409249,0.0004459452,0.00007804441,0.009835329,0.001172728,0.008559869],"genre_scores_gemma":[0.9625599,0.001804038,0.03081746,0.0005417847,0.0002063236,0.00003812209,0.002017106,0.0001882321,0.001827016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007168413,"threshold_uncertainty_score":0.02398074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171762429043856,"score_gpt":0.2384154847586767,"score_spread":0.2212392418542911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}